SNX5 and MIB1

Number of citations of the paper that reports this interaction (PubMedID 16857196)
17

Data Source:
HPRD (two hybrid)

		SNX5	MIB1
Description		sorting nexin 5	mindbomb E3 ubiquitin protein ligase 1
Image
GO Annotations	Cellular Component	Ruffle Phagocytic Cup Endosome Cytosol Brush Border Cytoplasmic Vesicle Membrane Retromer Complex Retromer, Tubulation Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extrinsic Component Of Endosome Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Macropinocytic Cup Tubular Endosome	Cytoplasm Centrosome Cytosol Plasma Membrane Postsynaptic Density Cytoplasmic Vesicle
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding D1 Dopamine Receptor Binding Dynactin Binding Phosphatidylinositol Binding Cadherin Binding Protein Heterodimerization Activity Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding
	Biological Process	Intracellular Protein Transport Pinocytosis Epidermal Growth Factor Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Renal Sodium Excretion Retrograde Transport, Endosome To Golgi Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Insulin Receptor Signaling Pathway	Blood Vessel Development In Utero Embryonic Development Somitogenesis Neural Tube Formation Heart Looping Ubiquitin-dependent Protein Catabolic Process Endocytosis Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of Neuron Differentiation Positive Regulation Of Endocytosis
Pathways		Golgi Associated Vesicle Biogenesis	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS		Cholesterol, total ( 25961943) LDL cholesterol ( 24097068 25961943) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Severe progression in rheumatoid arthritis ( 29065906)
Interacting Genes		15 interacting genes: APPBP2 AQP2 CDC37 CLTC CLTCL1 DNAJB11 FANCA HGS HMOX2 ITSN1 MESD MIB1 PFDN1 PRKRA SNX2	20 interacting genes: AZI2 BLM CABLES1 CEP131 CHST9 DAB2 DAPK1 EPB41L4A GABARAP JAG1 RMC1 SNX5 TBK1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2U UBE2W
Entrez ID		27131	57534
HPRD ID		10439	06660
Ensembl ID		ENSG00000089006	ENSG00000101752
Uniprot IDs		Q6P5V6 Q9Y5X3	Q86YT6
PDB IDs		1SYS 5TGH 5TGI 5TGJ 5WY2 6N5X 6N5Y 6N5Z	4TSE 4XI6 4XI7 4XIB
Enriched GO Terms of Interacting Partners?
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