GJB1 and VKORC1

Number of citations of the paper that reports this interaction (PubMedID 21103663)
7

Data Source:
BioGRID (two hybrid)

		GJB1	VKORC1
Description		gap junction protein beta 1	vitamin K epoxide reductase complex subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Connexin Complex Integral Component Of Membrane Lateral Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Gap Junction Channel Activity	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Quinone Binding
	Biological Process	Cell-cell Signaling Nervous System Development Purine Ribonucleotide Transport Gap Junction Assembly Transmembrane Transport Epididymis Development	Blood Coagulation Response To Organonitrogen Compound Response To Organic Cyclic Compound Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Regulation Of Blood Coagulation Vitamin K Metabolic Process Response To Antibiotic Oxidation-reduction Process Bone Development
Pathways		Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly	Metabolism of vitamin K
Drugs			Menadione Dicoumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Combined deficiency of vitamin K-dependent clotting factors (VKCFD)
GWAS			Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Body fat distribution (arm fat ratio) ( 30664634) Warfarin maintenance dose ( 18535201 20833655 19300499 26265036) Warfarin maintenance dose (adjusted for clinical factors) ( 28686080)
Interacting Genes		13 interacting genes: APP CALM1 CNST EGFR EPHA1 GJB2 GLP1R MST1R PRKACA PRKCA PTPN2 SRC VKORC1	83 interacting genes: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5MC3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CREB3 CXADR DCTPP1 DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 LMNA METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM35B TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24
Entrez ID		2705	79001
HPRD ID		02367	10540
Ensembl ID		ENSG00000169562	ENSG00000167397
Uniprot IDs		P08034	A0A0S2Z5X7 A0A0S2Z6I4 Q9BQB6
PDB IDs		1TXH 5KK9
Enriched GO Terms of Interacting Partners?
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