GJB1 and EPHA1

Number of citations of the paper that reports this interaction (PubMedID 30401746)
0

Data Source:
BioGRID (enzymatic study)

		GJB1	EPHA1
Description		gap junction protein beta 1	EPH receptor A1
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Connexin Complex Integral Component Of Membrane Lateral Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Dendritic Spine Receptor Complex
	Molecular Function	Gap Junction Channel Activity	Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity ATP Binding Protein Kinase Binding
	Biological Process	Cell-cell Signaling Nervous System Development Purine Ribonucleotide Transport Gap Junction Assembly Transmembrane Transport Epididymis Development	Angiogenesis Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Positive Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Kinase Activity Substrate Adhesion-dependent Cell Spreading Somatic Stem Cell Population Maintenance Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Activation Of GTPase Activity
Pathways		Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly	EPH-Ephrin signaling EPH-Ephrin signaling POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576 29875488 28240269) Family history of Alzheimer's disease ( 30617256)
Interacting Genes		13 interacting genes: APP CALM1 CNST EGFR EPHA1 GJB2 GLP1R MST1R PRKACA PRKCA PTPN2 SRC VKORC1	12 interacting genes: CTDSP2 DAPK1 DUSP14 EFNA1 ERBB2 GJB1 MAP3K1 MTMR14 PTPN11 SMURF1 SMURF2 TPTE
Entrez ID		2705	2041
HPRD ID		02367	01554
Ensembl ID		ENSG00000169562	ENSG00000146904
Uniprot IDs		P08034	P21709
PDB IDs		1TXH 5KK9	2K1K 2K1L 3HIL 3KKA
Enriched GO Terms of Interacting Partners?
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