GCG and CPE

Number of citations of the paper that reports this interaction (PubMedID 11375130)
7

Data Source:
HPRD (in vivo)

		GCG	CPE
Description		glucagon	carboxypeptidase E
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Lumen	Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Hormone Activity Protein Binding Glucagon Receptor Binding Identical Protein Binding	Carboxypeptidase Activity Metallocarboxypeptidase Activity Zinc Ion Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Protein Kinase A Signaling Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Kinase Activity Regulation Of Insulin Secretion Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucagon Stimulus Positive Regulation Of Calcium Ion Import Negative Regulation Of Execution Phase Of Apoptosis	Cardiac Left Ventricle Morphogenesis Cellular Protein Modification Process Peptide Metabolic Process Neuropeptide Signaling Pathway Wnt Signaling Pathway Protein Processing Insulin Processing Peptide Hormone Secretion Protein Localization To Secretory Granule Protein Localization To Membrane
Pathways		Glucagon signaling in metabolic regulation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors Synthesis, secretion, and deacylation of Ghrelin ADORA2B mediated anti-inflammatory cytokines production	Insulin processing
Drugs			Insulin Human Insulin Pork
Diseases
GWAS		Regular attendance at a pub or social club ( 29970889)	Pelvic organ prolapse (moderate/severe) ( 26545240) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		7 interacting genes: CPE CTSL GCGR GLP1R GLP2R MEP1A MEP1B	17 interacting genes: BDNF CCK CHD3 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A
Entrez ID		2641	1363
HPRD ID		00676	00272
Ensembl ID		ENSG00000115263	ENSG00000109472
Uniprot IDs		P01275	A0A384N679 P16870
PDB IDs		1BH0 1D0R 1NAU 2G49 2L63 2L64 2M5P 2M5Q 3IOL 4APD 4ZGM 5OTU 5OTV 5OTW 5OTX 5VAI 5YQZ 6EDS 6NZN
Enriched GO Terms of Interacting Partners?
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