CPE and MED31

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CPE	MED31
Description		carboxypeptidase E	mediator complex subunit 31
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Extracellular Exosome	Ubiquitin Ligase Complex Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Zinc Ion Binding Neurexin Family Protein Binding Cell Adhesion Molecule Binding	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cardiac Left Ventricle Morphogenesis Cellular Protein Modification Process Peptide Metabolic Process Neuropeptide Signaling Pathway Wnt Signaling Pathway Protein Processing Insulin Processing Peptide Hormone Secretion Protein Localization To Secretory Granule Protein Localization To Membrane	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Negative Regulation Of Fibroblast Proliferation Limb Development
Pathways		Insulin processing	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs		Insulin Human Insulin Pork
Diseases
GWAS		Pelvic organ prolapse (moderate/severe) ( 26545240) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		17 interacting genes: BDNF CCK CHD3 GAST GCG GTF3C1 INS LRIF1 MED31 NTS PMCH POLA2 POLDIP2 ROBO2 RPA1 TRH UTP14A	58 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1
Entrez ID		1363	51003
HPRD ID		00272	14382
Ensembl ID		ENSG00000109472	ENSG00000108590
Uniprot IDs		A0A384N679 P16870	Q9Y3C7
PDB IDs
Enriched GO Terms of Interacting Partners?
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