GATA2 and POU2AF1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		GATA2	POU2AF1
Description		GATA binding protein 2	POU class 2 homeobox associating factor 1
Image
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Protein-containing Complex	RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding C2H2 Zinc Finger Domain Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Urogenital System Development Cell Fate Determination Neuron Migration Embryonic Placenta Development Transcription, DNA-templated Phagocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Primitive Erythrocyte Differentiation Ventral Spinal Cord Interneuron Differentiation Cell Differentiation In Hindbrain Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Central Nervous System Neuron Development Pituitary Gland Development Response To Lipid Somatic Stem Cell Population Maintenance Regulation Of Histone Acetylation Eosinophil Fate Commitment Inner Ear Morphogenesis Positive Regulation Of Mast Cell Degranulation Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Phagocytosis Positive Regulation Of Phagocytosis, Engulfment Definitive Hemopoiesis Semicircular Canal Development Negative Regulation Of Fat Cell Proliferation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cochlea Development GABAergic Neuron Differentiation Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Forebrain Neuron Differentiation	Transcription By RNA Polymerase II Humoral Immune Response Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 30578418) Eosinophil counts ( 19198610) Lymphocyte percentage of white cells ( 27863252) Neutrophil percentage of white cells ( 27863252) Preterm birth (maternal effect) ( 28877031) Prostate cancer ( 31562322) Pulse pressure ( 28135244 27841878 30578418) Systolic blood pressure ( 27841878) White blood cell count ( 21738480) White blood cell count (basophil) ( 28158719) White blood cell count (eosinophil) ( 28158719) White blood cell types ( 21738478)	Celiac disease ( 22057235) Corneal structure ( 23291589) Diverticular disease ( 30177863) Hodgkin's lymphoma ( 30194254) Low urine pH ( 30476138) Multiple sclerosis ( 31604244) Primary biliary cholangitis ( 23000144 28062665) Serum urea levels ( 30808845) Urine pH measurement ( 30476138)
Interacting Genes		36 interacting genes: ADAMTSL4 AKT1 CDK1 CEBPA EP300 FBXW7 FHL3 GOLGA2 HDAC3 HDAC5 HHEX JUN KAT2A KRT40 KRTAP10-3 KRTAP10-9 LMO2 MAPK1 MDFI NOTCH2NLA PML POU1F1 POU2AF1 PRR20A PSMA3 RARA RXRA SMAD4 SPI1 STAT3 TAL1 TRAF1 TRIM23 ZBTB16 ZBTB32 ZFPM1	19 interacting genes: GATA2 GCC2 GTF2H1 GTF2I MSX2 NAB1 NOTCH1 PAX8 POU2F1 POU2F2 PTPN11 RHOXF2 SIAH1 SIAH2 SLC22A1 SLC22A2 SMAD2 SUB1 SYK
Entrez ID		2624	5450
HPRD ID		00673	03126
Ensembl ID		ENSG00000179348	ENSG00000110777
Uniprot IDs		P23769	Q16633
PDB IDs		5O9B	1CQT
Enriched GO Terms of Interacting Partners?
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