WSB1 and CSF3R

Number of citations of the paper that reports this interaction (PubMedID 17001306)
5

Data Source:
BioGRID (affinity chromatography technology, protein complementation assay)

		WSB1	CSF3R
Description		WD repeat and SOCS box containing 1	colony stimulating factor 3 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Intracellular Cytosol	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding	Cytokine Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Granulocyte Colony-stimulating Factor Binding
	Biological Process	Protein Polyubiquitination Biological_process Intracellular Signal Transduction Post-translational Protein Modification	Defense Response Cell Adhesion Signal Transduction Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Regulation Of Myeloid Cell Differentiation Amelogenesis
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Other interleukin signaling Transcriptional regulation of granulopoiesis
Drugs			Pegfilgrastim Filgrastim FavId Lenograstim
Diseases
GWAS		Birth weight ( 31043758) Chronic myeloid leukemia ( 21540461) Dental caries ( 23064961)	Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Iron status biomarkers (total iron binding capacity) ( 28334935) Lymphocyte percentage of white cells ( 27863252) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 29403010 27863252)
Interacting Genes		7 interacting genes: CSF3R DIO2 GSK3B HIPK2 LRRK2 UBE2D2 UBE2D3	19 interacting genes: CISH CSF3 ELANE FTH1 GRB2 HCK INPP5D JAK1 JAK2 LCK LYN PLA2G1B PTPN11 SHC1 SOCS3 STAT3 SYK WSB1 WSB2
Entrez ID		26118	1441
HPRD ID		15680	00737
Ensembl ID		ENSG00000109046	ENSG00000119535
Uniprot IDs		A0A024QZ36 A0A024QZ51 Q8NC76 Q9Y6I7	Q99062
PDB IDs			1AZ7 2D9Q
Enriched GO Terms of Interacting Partners?
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