ERC2 and PPFIA1

Number of citations of the paper that reports this interaction (PubMedID 12923177)
60

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		ERC2	PPFIA1
Description		ELKS/RAB6-interacting/CAST family member 2	PTPRF interacting protein alpha 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Cell Junction Growth Cone Presynaptic Membrane Presynaptic Active Zone Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse GABA-ergic Synapse	Cytoplasm Cytosol Focal Adhesion Axon Dendrite Protein-containing Complex Presynaptic Active Zone
	Molecular Function	Protein Binding Structural Constituent Of Presynaptic Active Zone	Protein Binding
	Biological Process	Synaptic Vesicle Priming Maintenance Of Presynaptic Active Zone Structure	Cell-matrix Adhesion Signal Transduction Neurotransmitter Secretion Glutamate Secretion Synapse Organization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Protein Localization To Plasma Membrane
Pathways			Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 22076464) Alcohol dependence ( 24166409) Bipolar disorder and schizophrenia ( 21057379) Chronotype ( 26955885) Daytime sleep phenotypes ( 27126917) Heel bone mineral density ( 30598549 28869591) Hip bone size ( 31053729) Hip geometry ( 17903296) Intertrochanteric region size ( 31053729) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Morning vs. evening chronotype ( 26955885 27494321) Night sleep phenotypes ( 27126917) Periodontitis (Mean PAL) ( 24024966) Post bronchodilator FEV1/FVC ratio ( 26634245) Sense of smell ( 26632684) Tourette syndrome ( 30818990) Trochanter size ( 31053729)	Coronary artery disease ( 29212778)
Interacting Genes		8 interacting genes: BSN MYB PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1	26 interacting genes: AGTPBP1 CAGE1 CAST CCNH CEP70 DNAJC5 DTNB ERC1 ERC2 FAM161A GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5D PTPRC PTPRD PTPRF PTPRS TNNT1 TXLNA YWHAG
Entrez ID		26059	8500
HPRD ID		10810	11451
Ensembl ID		ENSG00000187672	ENSG00000131626
Uniprot IDs		O15083	B3KVS8 Q13136
PDB IDs			1N7F
Enriched GO Terms of Interacting Partners?
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