SS18L1 and SMARCA4

Number of citations of the paper that reports this interaction (PubMedID 19081374)
45

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SS18L1	SMARCA4
Description		SS18L1 subunit of BAF chromatin remodeling complex	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome, Centromeric Region Nucleus Nucleoplasm Cytosol Nuclear Body NBAF Complex	Nuclear Chromatin Extracellular Space Nucleus Nucleoplasm Nucleolus Membrane SWI/SNF Complex Protein-containing Complex NpBAF Complex NBAF Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase I CORE Element Sequence-specific DNA Binding P53 Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Transcription Factor Binding Tat Protein Binding Nucleosomal DNA Binding Protein N-terminus Binding Androgen Receptor Binding DNA Polymerase Binding Lysine-acetylated Histone Binding
	Biological Process	Chromatin Organization Dendrite Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Dendrite Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase I Preinitiation Complex Assembly Neural Retina Development Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Interleukin-7-mediated Signaling Pathway ATP-dependent Chromatin Remodeling Positive Regulation By Host Of Viral Transcription Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Glucose Mediated Signaling Pathway Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Beta-catenin-TCF Complex Assembly
Pathways			Interleukin-7 signaling Formation of the beta-catenin:TCF transactivating complex RMTs methylate histone arginines Chromatin modifying enzymes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS			Coronary artery disease ( 24262325 30104761) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Disorders of lipid metabolism ( 30166351) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Inflammatory skin disease ( 25574825) Ischemic stroke ( 29531354) LDL cholesterol ( 21347282) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Medication use (HMG CoA reductase inhibitors) ( 31015401) Multiple sclerosis ( 31604244) Stroke ( 29531354)
Interacting Genes		31 interacting genes: AATF ANKRD22 ATF3 BRD1 CREBBP CSTF2 DGCR6 ELF5 EP300 FAM168A GATAD1 HDAC2 HDAC4 HGS LGALS3 MAPK1IP1L MED30 MIA2 NR1H3 PCGF6 RFX6 RLIM SF3B4 SMAD1 SMAD3 SMARCA4 SNRPB SNRPC STAT3 TAF9B TCF7	78 interacting genes: ACTB ACTL6A AHR AR ARID1A ARID1B ARID2 BRCA1 BRWD1 CARM1 CBX5 CCNE1 CDK19 CDK8 CDKN2A CDX2 CEBPA CEBPB CHD4 CHFR CHMP5 CIITA CREB1 CTNNB1 E2F6 ESR1 ETS2 FANCA GATA1 GMNN H2AX H2BC21 H3-3A H3C1 H3C14 H4C6 HSF1 HSF4 HSPB1 IKZF1 KLF1 MBD3 MDM2 MED17 MED6 MPHOSPH6 MPP6 MRTFA MYC MYOCD NR3C1 NR4A2 PABPN1 PAX6 PBRM1 PHB RAP1A RASSF1 RB1 RBL1 RBL2 RELB RFXAP SIN3A SIN3B SMARCB1 SMARCC1 SMARCE1 SOX4 SS18 SS18L1 STAT2 STAT3 STK11 TAF15 TMF1 TP53 ZMYND11
Entrez ID		26039	6597
HPRD ID		09398	04459
Ensembl ID		ENSG00000184402	ENSG00000127616
Uniprot IDs		B4DSR7 O75177	A7E2E1 B3KNW7 P51532 Q9HBD4
PDB IDs			2GRC 2H60 3UVD 5DKD 5EA1 6BGH 6HR2
Enriched GO Terms of Interacting Partners?
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