ZZZ3 and MAML3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		ZZZ3	MAML3
Description		zinc finger ZZ-type containing 3	mastermind like transcriptional coactivator 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Nucleolus	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding	Transcription Coactivator Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II
Pathways		HATs acetylate histones	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Height ( 31562340) Hip circumference ( 25673412) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Obesity ( 23563607) Type 2 diabetes (age of onset) ( 28060188)	Borderline personality disorder ( 28632202) Chronic mucus hypersecretion ( 25234806) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Congenital heart malformation ( 23708190) Gastroesophageal reflux disease ( 31527586) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Multisite chronic pain ( 31194737) Social science traits (pleiotropy) (HIPO component 1) ( 30289880)
Interacting Genes		15 interacting genes: BLZF1 DNAJB11 EPS8 FAM124A GATA1 IKBKG LZTR1 MAML3 PBXIP1 PCBD2 TRIM22 ZBTB9 ZNF212 ZNF496 ZNF513	10 interacting genes: NFX1 NOTCH1 NOTCH2 NOTCH3 NOTCH4 RAI1 SCMH1 SUPT5H ZBTB1 ZZZ3
Entrez ID		26009	55534
HPRD ID		15907	10066
Ensembl ID		ENSG00000036549	ENSG00000196782
Uniprot IDs		Q8IYH5	Q96JK9 Q9NPV6
PDB IDs		2FC7 2YUM 6E83 6E86
Enriched GO Terms of Interacting Partners?
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