BAG4 and TNFRSF25

Number of citations of the paper that reports this interaction (PubMedID 9915703)
78

Data Source:
HPRD (in vivo, two hybrid)

		BAG4	TNFRSF25
Description		BAG cochaperone 4	TNF receptor superfamily member 25
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Chaperone Binding	Tumor Necrosis Factor-activated Receptor Activity Signaling Receptor Activity
	Biological Process	Protein Folding Positive Regulation Of Fibroblast Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Ruffle Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity	Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Apoptotic Signaling Pathway
Pathways		Regulation of HSF1-mediated heat shock response Signaling by FGFR1 in disease TNF signaling Signaling by plasma membrane FGFR1 fusions	TNFs bind their physiological receptors
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		38 interacting genes: APOBEC1 ATAD2 BAP1 BCAS3 BCL2 BEX1 CASZ1 CCL5 DIRAS3 EPSTI1 ERRFI1 GLCE GRAP2 HSPA1A HSPA8 IL13RA2 IL24 ITIH5 KLK5 KLK7 KLK9 LRATD2 LYPD3 MRC2 MTA3 NAT2 PDLIM2 PLAT PRDM14 RASL10B RHOBTB2 RNF20 RPL22 SCGB3A1 TBC1D7 THRSP TNFRSF1A TNFRSF25	8 interacting genes: BAG4 DAP3 MAPK1 TNFRSF1A TNFSF12 TNFSF15 TRADD TRAF2
Entrez ID		9530	8718
HPRD ID		04861	04532
Ensembl ID		ENSG00000156735	ENSG00000215788
Uniprot IDs		O95429	Q93038
PDB IDs		1M62 1M7K	5YGP 5YGS
Enriched GO Terms of Interacting Partners?
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