GABRB2 and PPP3CA

Number of citations of the paper that reports this interaction (PubMedID 12574411)
44

Data Source:
HPRD (in vitro)

		GABRB2	PPP3CA
Description		gamma-aminobutyric acid type A receptor subunit beta2	protein phosphatase 3 catalytic subunit alpha
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Cytoplasmic Vesicle Membrane Chloride Channel Complex Neuron Projection Synapse Extracellular Exosome GABA-ergic Synapse Integral Component Of Postsynaptic Specialization Membrane GABA-A Receptor Complex	Cell Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Calcineurin Complex Cytoplasmic Side Of Plasma Membrane Extrinsic Component Of Plasma Membrane Z Disc Slit Diaphragm Sarcolemma Dendritic Spine Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	GABA-A Receptor Activity Inhibitory Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity GABA Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Cyclosporin A Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein-containing Complex Binding Protein Dimerization Activity ATPase Binding
	Biological Process	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Sensory Perception Of Sound Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Neuron Apoptotic Process Nervous System Process Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Inner Ear Receptor Cell Development Innervation Cellular Response To Histamine Cochlea Development Chloride Transmembrane Transport Inhibitory Synapse Assembly	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Wnt Signaling Pathway, Calcium Modulating Pathway Brain Development Aging Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Dephosphorylation Positive Regulation Of Cell Migration Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Negative Regulation Of Chromatin Binding Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway T Cell Activation Skeletal Muscle Tissue Regeneration Positive Regulation Of Cell Adhesion Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Response To Calcium Ion Excitatory Postsynaptic Potential Peptidyl-serine Dephosphorylation Cellular Response To Glucose Stimulus Calcineurin-mediated Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Connective Tissue Replacement
Pathways		Signaling by ERBB4 GABA receptor activation GABA receptor activation	DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Topiramate Etomidate Talbutal Pentobarbital Olanzapine Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Metharbital Chlordiazepoxide Amoxapine Adinazolam Clorazepate Acamprosate Midazolam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Ethanol Methoxyflurane Ergoloid mesylate Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Estazolam Sevoflurane Ginkgo biloba Glutethimide Bromazepam Clotiazepam Fludiazepam Prazepam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Fospropofol Stiripentol Thiocolchicoside	Myristic acid
Diseases
GWAS		Multisite chronic pain ( 31194737) Perceived intensity of sweet substances ( 31005972) Plasma neurofilament light levels ( 29747637)	Anorexia nervosa ( 24514567) Bitter non-alcoholic beverage consumption ( 31046077) Blood pressure ( 22763476) Chronotype ( 30696823) Corneal structure ( 21979947) Trunk fat mass ( 28552196) Vitiligo ( 27723757)
Interacting Genes		5 interacting genes: ARFGEF2 PPP3CA PRKCB TRAK2 UBQLN1	31 interacting genes: AATK AKAP5 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FGFR4 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 KCNIP3 KLHL3 MARCHF7 MYOZ2 MYOZ3 PPP3R1 PRKCZ PTK7 RCAN1 RCAN2 RYK SOD1 STUB1 SYNJ1 UBE4B
Entrez ID		2561	5530
HPRD ID		02578	00234
Ensembl ID		ENSG00000145864	ENSG00000138814
Uniprot IDs		P47870	A0A0S2Z4B5 A0A0S2Z4C6 Q08209
PDB IDs		6D6T 6D6U	1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z 4Q5U 5C1V 5SVE 6NUC 6NUF 6NUU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?