GABRB2 and ARFGEF2

Number of citations of the paper that reports this interaction (PubMedID 15198677)
44

Data Source:
HPRD (two hybrid)

		GABRB2	ARFGEF2
Description		gamma-aminobutyric acid type A receptor subunit beta2	ADP ribosylation factor guanine nucleotide exchange factor 2
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Cytoplasmic Vesicle Membrane Chloride Channel Complex Neuron Projection Synapse Extracellular Exosome GABA-ergic Synapse Integral Component Of Postsynaptic Specialization Membrane GABA-A Receptor Complex	Golgi Membrane Trans-Golgi Network Microtubule Organizing Center Cytosol Axonemal Microtubule Membrane Cell Junction Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Dendritic Spine Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	GABA-A Receptor Activity Inhibitory Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity GABA Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Guanyl-nucleotide Exchange Factor Activity ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding
	Biological Process	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Sensory Perception Of Sound Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Neuron Apoptotic Process Nervous System Process Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Inner Ear Receptor Cell Development Innervation Cellular Response To Histamine Cochlea Development Chloride Transmembrane Transport Inhibitory Synapse Assembly	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction
Pathways		Signaling by ERBB4 GABA receptor activation GABA receptor activation	Association of TriC/CCT with target proteins during biosynthesis
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Topiramate Etomidate Talbutal Pentobarbital Olanzapine Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Metharbital Chlordiazepoxide Amoxapine Adinazolam Clorazepate Acamprosate Midazolam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Ethanol Methoxyflurane Ergoloid mesylate Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Estazolam Sevoflurane Ginkgo biloba Glutethimide Bromazepam Clotiazepam Fludiazepam Prazepam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Fospropofol Stiripentol Thiocolchicoside
Diseases			Periventricular nodular heterotopia (PVNH)
GWAS		Multisite chronic pain ( 31194737) Perceived intensity of sweet substances ( 31005972) Plasma neurofilament light levels ( 29747637)	Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625)
Interacting Genes		5 interacting genes: ARFGEF2 PPP3CA PRKCB TRAK2 UBQLN1	9 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 PNPLA2 PRKAR1A PRKAR2A PRPF40A
Entrez ID		2561	10564
HPRD ID		02578	09250
Ensembl ID		ENSG00000145864	ENSG00000124198
Uniprot IDs		P47870	Q59FR3 Q86TH5 Q9Y6D5
PDB IDs		6D6T 6D6U	3L8N 3SWV
Enriched GO Terms of Interacting Partners?
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