PPP3CA and GABRG2

Number of citations of the paper that reports this interaction (PubMedID 12574411)
44

Data Source:
HPRD (in vitro)

		PPP3CA	GABRG2
Description		protein phosphatase 3 catalytic subunit alpha	gamma-aminobutyric acid type A receptor subunit gamma2
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GO Annotations	Cellular Component	Cell Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Calcineurin Complex Cytoplasmic Side Of Plasma Membrane Extrinsic Component Of Plasma Membrane Z Disc Slit Diaphragm Sarcolemma Dendritic Spine Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Axon Cytoplasmic Vesicle Membrane Dendrite Membrane Chloride Channel Complex Neuron Projection Synapse Postsynaptic Membrane Postsynapse GABA-ergic Synapse GABA-A Receptor Complex
	Molecular Function	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Cyclosporin A Binding Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Protein-containing Complex Binding Protein Dimerization Activity ATPase Binding	GABA-A Receptor Activity Inhibitory Extracellular Ligand-gated Ion Channel Activity Chloride Channel Activity Protein Binding Benzodiazepine Receptor Activity GABA-gated Chloride Ion Channel Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Amphetamine Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Wnt Signaling Pathway, Calcium Modulating Pathway Brain Development Aging Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Dephosphorylation Positive Regulation Of Cell Migration Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Negative Regulation Of Chromatin Binding Cellular Response To Drug Fc-epsilon Receptor Signaling Pathway T Cell Activation Skeletal Muscle Tissue Regeneration Positive Regulation Of Cell Adhesion Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Secretion Skeletal Muscle Fiber Development Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Response To Calcium Ion Excitatory Postsynaptic Potential Peptidyl-serine Dephosphorylation Cellular Response To Glucose Stimulus Calcineurin-mediated Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Connective Tissue Replacement	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Post-embryonic Development Adult Behavior Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Histamine Chloride Transmembrane Transport Inhibitory Synapse Assembly
Pathways		DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs		Myristic acid	Lorazepam Ethchlorvynol Enflurane Temazepam Temazepam Butabarbital Butalbital Topiramate Etomidate Talbutal Pentobarbital Olanzapine Clobazam Meprobamate Carisoprodol Eszopiclone Alprazolam Zolpidem Metharbital Chlordiazepoxide Amoxapine Adinazolam Clorazepate Acamprosate Midazolam Flurazepam Isoflurane Primidone Halazepam Halazepam Propofol Diazepam Diazepam Oxazepam Oxazepam Triazolam Triazolam Methoxyflurane Ergoloid mesylate Clonazepam Methyprylon Halothane Desflurane Flumazenil Flumazenil Estazolam Estazolam Sevoflurane Ginkgo biloba Glutethimide Flunitrazepam Bromazepam Clotiazepam Fludiazepam Prazepam Prazepam Quazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Adipiplon Stiripentol Etizolam Thiocolchicoside Muscimol Lormetazepam
Diseases			Febrile seizures, including: Febrile convulsions; Generalized epilepsy with febrile seizure plus (GEFS+); Dravet syndrome/ Severe myoclonic epilepsy in infancy (SMEI) Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Anorexia nervosa ( 24514567) Bitter non-alcoholic beverage consumption ( 31046077) Blood pressure ( 22763476) Chronotype ( 30696823) Corneal structure ( 21979947) Trunk fat mass ( 28552196) Vitiligo ( 27723757)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Cognitive decline rate in late mild cognitive impairment ( 26252872) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Severe influenza A (H1N1) infection ( 26379185)
Interacting Genes		31 interacting genes: AATK AKAP5 ATP2B4 BAD BCL2 C16orf74 CABIN1 CASP3 CRTC2 FGFR4 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 KCNIP3 KLHL3 MARCHF7 MYOZ2 MYOZ3 PPP3R1 PRKCZ PTK7 RCAN1 RCAN2 RYK SOD1 STUB1 SYNJ1 UBE4B	8 interacting genes: DRD5 GABARAP GABRA2 LARP7 PPP3CA PRKCA PRKCB ZDHHC3
Entrez ID		5530	2566
HPRD ID		00234	00663
Ensembl ID		ENSG00000138814	ENSG00000113327
Uniprot IDs		A0A0S2Z4B5 A0A0S2Z4C6 Q08209	P18507
PDB IDs		1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z 4Q5U 5C1V 5SVE 6NUC 6NUF 6NUU	6D6T 6D6U 6HUG 6HUJ 6HUK 6HUO 6HUP 6I53
Enriched GO Terms of Interacting Partners?
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