FXN and PICK1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		FXN	PICK1
Description		frataxin	protein interacting with PRKCA 1
Image
GO Annotations	Cellular Component	Cell Mitochondrion Mitochondrial Matrix Cytosol L-cysteine Desulfurase Complex	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Postsynaptic Density Aggresome Cell Junction Endocytic Vesicle Membrane Trans-Golgi Network Membrane Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Postsynaptic Early Endosome
	Molecular Function	Ferroxidase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Iron Chaperone Activity 2 Iron, 2 Sulfur Cluster Binding	G Protein-coupled Receptor Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Phospholipid Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding Membrane Curvature Sensor Activity
	Biological Process	Oxidative Phosphorylation Heme Biosynthetic Process Ion Transport Cellular Iron Ion Homeostasis Mitochondrion Organization Adult Walking Behavior Positive Regulation Of Cell Proliferation Aerobic Respiration Embryo Development Ending In Birth Or Egg Hatching Response To Iron Ion Regulation Of Ferrochelatase Activity Iron-sulfur Cluster Assembly Protein Autoprocessing Iron Incorporation Into Metallo-sulfur Cluster Proprioception Positive Regulation Of Cell Growth Negative Regulation Of Multicellular Organism Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Negative Regulation Of Organ Growth Positive Regulation Of Lyase Activity Cellular Response To Hydrogen Peroxide Negative Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Succinate Dehydrogenase Activity Positive Regulation Of Aconitate Hydratase Activity	Positive Regulation Of Receptor Internalization Protein Phosphorylation Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Monoamine Transport Glial Cell Development Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Regulation Of Insulin Secretion Long-term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance
Pathways		Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis	Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors
Drugs		Iron
Diseases		Friedreich ataxia
GWAS		Headache ( 29397368) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Seasonality ( 25562672)	Body fat percentage ( 26833246)
Interacting Genes		5 interacting genes: ACTN1 GGCX PICK1 PMPCB RNF126	47 interacting genes: AFDN AKT1 APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBIN F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIP1 GRM3 GRM7 JAM3 LRP2BP NECTIN2 NECTIN4 PRKCA PRKCG PRKN PRLHR SACS SLC6A3 UBQLN4 USP7
Entrez ID		2395	9463
HPRD ID		06013	16176
Ensembl ID		ENSG00000165060	ENSG00000100151
Uniprot IDs		A0A0S2Z3G4 Q16595	A0A024R1J5 Q9NRD5
PDB IDs		1EKG 1LY7 3S4M 3S5D 3S5E 3S5F 3T3J 3T3K 3T3L 3T3T 3T3X 5KZ5 6NZU	2GZV 6AR4 6BJN 6BJO
Enriched GO Terms of Interacting Partners?
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