PICK1 and NECTIN4

Number of citations of the paper that reports this interaction (PubMedID 15811349)
11

Data Source:
HPRD (two hybrid)

		PICK1	NECTIN4
Description		protein interacting with PRKCA 1	nectin cell adhesion molecule 4
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Postsynaptic Density Aggresome Cell Junction Endocytic Vesicle Membrane Trans-Golgi Network Membrane Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Postsynaptic Early Endosome	Plasma Membrane Adherens Junction Integral Component Of Membrane Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Phospholipid Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding Membrane Curvature Sensor Activity	Virus Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Positive Regulation Of Receptor Internalization Protein Phosphorylation Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Monoamine Transport Glial Cell Development Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Regulation Of Insulin Secretion Long-term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Viral Entry Into Host Cell
Pathways		Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors	Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases			Ectodermal dysplasia-syndactyly syndrome (EDSS)
GWAS		Body fat percentage ( 26833246)
Interacting Genes		47 interacting genes: AFDN AKT1 APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBIN F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIP1 GRM3 GRM7 JAM3 LRP2BP NECTIN2 NECTIN4 PRKCA PRKCG PRKN PRLHR SACS SLC6A3 UBQLN4 USP7	5 interacting genes: AFDN NECTIN1 NECTIN2 PICK1 TIGIT
Entrez ID		9463	81607
HPRD ID		16176	17934
Ensembl ID		ENSG00000100151	ENSG00000143217
Uniprot IDs		A0A024R1J5 Q9NRD5	K4PZ75 Q96NY8
PDB IDs		2GZV 6AR4 6BJN 6BJO	4FRW 4GJT 4JJH
Enriched GO Terms of Interacting Partners?
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