PICK1 and GFI1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PICK1	GFI1
Description		protein interacting with PRKCA 1	growth factor independent 1 transcriptional repressor
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Postsynaptic Density Aggresome Cell Junction Endocytic Vesicle Membrane Trans-Golgi Network Membrane Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Postsynaptic Early Endosome	Nucleus Nucleoplasm Nuclear Matrix Nuclear Body Transcriptional Repressor Complex
	Molecular Function	G Protein-coupled Receptor Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Phospholipid Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding Membrane Curvature Sensor Activity	DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Receptor Internalization Protein Phosphorylation Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Monoamine Transport Glial Cell Development Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Regulation Of Insulin Secretion Long-term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Vitamin D Biosynthetic Process Negative Regulation Of Neuron Projection Development Viral Process Hemopoiesis Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Toll-like Receptor Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Histone H3-K4 Methylation Positive Regulation Of Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide
Pathways		Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors	Transcriptional regulation of granulopoiesis
Drugs
Diseases
GWAS		Body fat percentage ( 26833246)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Multiple sclerosis ( 31604244) Multiple sclerosis and type 2 diabetes (pleiotropy) ( 26920376) Systemic lupus erythematosus ( 28714469)
Interacting Genes		47 interacting genes: AFDN AKT1 APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBIN F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIP1 GRM3 GRM7 JAM3 LRP2BP NECTIN2 NECTIN4 PRKCA PRKCG PRKN PRLHR SACS SLC6A3 UBQLN4 USP7	6 interacting genes: CSDE1 PIAS3 PICK1 RUNX1T1 SLC9A3R1 SPI1
Entrez ID		9463	2672
HPRD ID		16176	07527
Ensembl ID		ENSG00000100151	ENSG00000162676
Uniprot IDs		A0A024R1J5 Q9NRD5	Q99684
PDB IDs		2GZV 6AR4 6BJN 6BJO
Enriched GO Terms of Interacting Partners?
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