KPNA6 and NUP50

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		KPNA6	NUP50
Description		karyopherin subunit alpha 6	nucleoporin 50
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GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytosol Membrane Host Cell	Nuclear Pore Nucleoplasm Nuclear Membrane Intracellular Membrane-bounded Organelle Host Cell
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Protein Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Viral Genome Replication Evasion Or Tolerance Of Host Defense Response Positive Regulation Of Transcription By RNA Polymerase II Maternal Process Involved In Female Pregnancy Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Viral Life Cycle	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Viral Process Protein Sumoylation Viral Transcription Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat
Pathways			ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events
Drugs
Diseases
GWAS		Body mass index ( 26426971)
Interacting Genes		23 interacting genes: ANP32A ARNT BRCA1 CDKN1B CREBBP CSE1L EPAS1 FRG1BP HIF1A IL1A KEAP1 KPNB1 LMNA NOP2 NUP50 RAC1 RELB SKP2 SMARCB1 STAT1 STAT3 TAF9 ZNF131	10 interacting genes: APP CDKN1B IPO13 KPNA2 KPNA3 KPNA6 KPNB1 RAN SRPK2 XPO1
Entrez ID		23633	10762
HPRD ID		09465	05226
Ensembl ID		ENSG00000025800	ENSG00000093000
Uniprot IDs		O60684	A0A024R4X7 B4E2D3 Q9UKX7
PDB IDs		4UAD	2EC1 3TJ3
Enriched GO Terms of Interacting Partners?
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