KPNA6 and IL1A

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		KPNA6	IL1A
Description		karyopherin subunit alpha 6	interleukin 1 alpha
Image
GO Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytosol Membrane Host Cell	Extracellular Region Extracellular Space Cytosol
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding
	Biological Process	NLS-bearing Protein Import Into Nucleus Viral Genome Replication Evasion Or Tolerance Of Host Defense Response Positive Regulation Of Transcription By RNA Polymerase II Maternal Process Involved In Female Pregnancy Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Viral Life Cycle	Fever Generation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Inflammatory Response To Antigenic Stimulus Apoptotic Process Inflammatory Response Negative Regulation Of Cell Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Response To Copper Ion Positive Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Cell Division Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection
Drugs			Rilonacept
Diseases			Graft-versus-host disease
GWAS		Body mass index ( 26426971)	Dysmenorrheic pain severity ( 29855537) Endometriosis ( 20844546 28537267) Gestational age at birth (child effect) ( 31477735) Interleukin-1-receptor antagonist levels ( 22205395) Post-term birth ( 31477735) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		23 interacting genes: ANP32A ARNT BRCA1 CDKN1B CREBBP CSE1L EPAS1 FRG1BP HIF1A IL1A KEAP1 KPNB1 LMNA NOP2 NUP50 RAC1 RELB SKP2 SMARCB1 STAT1 STAT3 TAF9 ZNF131	11 interacting genes: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP KPNA6 MEOX2 NDN NFKBIE S100A13
Entrez ID		23633	3552
HPRD ID		09465	00988
Ensembl ID		ENSG00000025800	ENSG00000115008
Uniprot IDs		O60684	P01583
PDB IDs		4UAD	1ITA 2ILA 2KKI 2L5X 5UC6
Enriched GO Terms of Interacting Partners?
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