WBP2 and PAX8

Number of citations of the paper that reports this interaction (PubMedID 14531730)
6

Data Source:
HPRD (in vitro, in vivo)

		WBP2	PAX8
Description		WW domain binding protein 2	paired box 8
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Transcription Coactivator Activity Protein Binding Estrogen Receptor Binding Chromatin DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Thyroid-stimulating Hormone Receptor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Response To Progesterone Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Establishment Of Protein Localization Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Progesterone Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Positive Regulation Of Histone H3-K14 Acetylation	Urogenital System Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Ventricular Septum Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Sulfur Compound Metabolic Process Central Nervous System Development Anatomical Structure Morphogenesis Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Thyroid Gland Development Thyroid-stimulating Hormone Signaling Pathway Pronephric Field Specification Inner Ear Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Pronephros Development Cellular Response To Gonadotropin Stimulus Otic Vesicle Development Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Metanephric Epithelium Development Metanephric Distal Convoluted Tubule Development Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Metanephric Nephron Tubule Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Positive Regulation Of Metanephric DCT Cell Differentiation Positive Regulation Of Thyroid Hormone Generation Regulation Of Thyroid-stimulating Hormone Secretion
Pathways
Drugs
Diseases			Thyroid cancer Congenital nongoitrous hypothyroidism (CHNG)
GWAS			Blood urea nitrogen levels ( 31152163) Body mass index ( 28552196) Creatinine levels ( 29403010) Depressive symptom (sleep problems) (binary trait) ( 31530331) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 29403010) Lymphocyte counts ( 27863252) Mucinous ovarian carcinoma ( 26075790) Optic disc size ( 31809533) Renal function-related traits (BUN) ( 22797727) Sleep duration ( 27992416 27494321 25469926) Sleep duration (long sleep) ( 30846698) Sleep duration (oversleepers vs undersleepers) ( 27494321) Sleep duration (short sleep) ( 30846698) Sleep traits (multi-trait analysis) ( 27992416) Urate levels ( 31578528) Weight ( 28552196)
Interacting Genes		47 interacting genes: ANAPC1 ANKRD13A ANKRD13D ARCN1 CLEC4G COPA COPB1 COPB2 COPE COPG1 CUEDC1 DDX17 EEF1B2 EPN2 ESR1 GRPEL1 H4C1 HUWE1 ITCH KRT18 KRT8 KRT9 MAGEA4 MAGI1 MYO6 NEDD4 NEDD4L PAX8 POLH RHBDD3 RNF168 RPS27A RPS3 SDHA SEPTIN3 TDP2 TOLLIP TOM1L2 UBA52 UBC UBE3A UBQLN1 UIMC1 WWP1 WWP2 WWTR1 YAP1	11 interacting genes: ANXA7 CHUK CXCL9 EP300 ID2 NKX2-1 PKM POU2AF1 SERINC1 SMAD3 WBP2
Entrez ID		23558	7849
HPRD ID		06097	01335
Ensembl ID		ENSG00000132471	ENSG00000125618
Uniprot IDs		A0A024R8L1 Q969T9	A0A024R4X8 A0A024R524 Q06710 R9W7C9
PDB IDs			2K27
Enriched GO Terms of Interacting Partners?
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