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PRAME and RARA
Number of citations of the paper that reports this interaction (PubMedID
16179254
)
106
Data Source:
BioGRID
(two hybrid)
PRAME
RARA
Description
preferentially expressed antigen in melanoma
retinoic acid receptor alpha
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Plasma Membrane
Nuclear Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cell Surface
Actin Cytoskeleton
Dendrite
Perinuclear Region Of Cytoplasm
RNA Polymerase II Transcription Factor Complex
Molecular Function
Protein Binding
Retinoic Acid Receptor Binding
Translation Repressor Activity, MRNA Regulatory Element Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Retinoic Acid Binding
DNA-binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Transcription Coactivator Activity
Transcription Corepressor Activity
Nuclear Receptor Activity
Signaling Receptor Binding
Protein Binding
Transcription Factor Binding
Drug Binding
Zinc Ion Binding
Enzyme Binding
Protein Domain Specific Binding
Nuclear Receptor Transcription Coactivator Activity
Chromatin DNA Binding
Signaling Receptor Activity
Histone Deacetylase Binding
Protein Kinase B Binding
Retinoic Acid-responsive Element Binding
MRNA 5'-UTR Binding
Protein Kinase A Binding
Alpha-actinin Binding
Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
Biological Process
Apoptotic Process
Positive Regulation Of Cell Proliferation
Cell Differentiation
Regulation Of Growth
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Ureteric Bud Development
Neural Tube Closure
Liver Development
Glandular Epithelial Cell Development
Outflow Tract Septum Morphogenesis
Growth Plate Cartilage Development
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Signal Transduction
Multicellular Organism Development
Germ Cell Development
Spermatogenesis
Female Pregnancy
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Hormone-mediated Signaling Pathway
Negative Regulation Of Translation
Hippocampus Development
Cell Differentiation
Prostate Gland Development
Negative Regulation Of Granulocyte Differentiation
Embryonic Camera-type Eye Development
Regulation Of Myelination
Response To Estradiol
Response To Retinoic Acid
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
Response To Vitamin A
Response To Lipid
Response To Cytokine
Multicellular Organism Growth
Negative Regulation Of Apoptotic Process
Apoptotic Cell Clearance
Steroid Hormone Mediated Signaling Pathway
Response To Ethanol
Positive Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Neuron Differentiation
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Synaptic Plasticity
Retinoic Acid Receptor Signaling Pathway
Embryonic Organ Development
Gland Development
Positive Regulation Of Binding
Ventricular Cardiac Muscle Cell Differentiation
Sertoli Cell Fate Commitment
Limb Development
Face Development
Bone Morphogenesis
Epithelium Development
Trachea Cartilage Development
Chondroblast Differentiation
Negative Regulation Of Cartilage Development
Cellular Response To Lipopolysaccharide
Cellular Response To Retinoic Acid
Cellular Response To Estrogen Stimulus
Pathways
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
Signaling by Retinoic Acid
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Drugs
Adapalene
Acitretin
Alitretinoin
Tretinoin
Tazarotene
Etretinate
Isotretinoin
Tamibarotene
LGD-1550
Diseases
Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
Acute myeloid leukemia (AML)
GWAS
Asthma (
31619474
)
Interacting Genes
9 interacting genes:
ELOB
ELOC
FBXO7
RARA
RBX1
STK19
UBC
XRN2
ZNF408
89 interacting genes:
ACTN4
AKT1
ARID1A
ARID5A
ARNTL
BAG1
BTG1
CCND3
CDK7
CEBPA
CLOCK
CNOT1
COPS2
E2F1
ESR1
FGFR1
FN1
FOXO1
GADD45G
GATA2
HDAC1
HDAC3
HDAC4
HMGA1
HR
IRX4
ITGB1BP2
KAT2B
KDM5A
KLF5
LRIF1
MAPK6
MDM2
MECR
MED1
MED25
MED6
MMS19
NCOA1
NCOA2
NCOA3
NCOA6
NCOR1
NCOR2
NKX2-1
NPAS2
NR0B2
NR1H2
NR1H3
NR2E3
NR3C1
NRBF2
NRIP1
NRIP2
NSD1
PARP1
PHF8
PIN1
PML
PNRC2
POU2F1
PRAME
PRDX6
PRKCA
PSMC5
RXRA
RXRB
RXRG
S100A3
SIRT1
SMARCD3
SNW1
SP1
SPEN
SRC
SRF
STAT5B
TADA3
TEKT4
THRB
TNIP1
TOP2B
TRIB3
TRIM24
TRIP4
UBE3A
UBQLN1
USP7
ZBTB16
Entrez ID
23532
5914
HPRD ID
05820
06769
Ensembl ID
ENSG00000185686
ENSG00000131759
Uniprot IDs
A0A024R1E6
B7Z7K8
B7Z986
B7ZAT0
P78395
A8K840
A8MUP8
F1D8N9
P10276
Q6I9R7
PDB IDs
1DKF
1DSZ
3A9E
3KMR
3KMZ
4DQM
5K13
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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