MACF1 and DISC1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
168

Data Source:
BioGRID (two hybrid)

		MACF1	DISC1
Description		microtubule actin crosslinking factor 1	DISC1 scaffold protein
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Actin Cytoskeleton Membrane Ruffle Membrane	Nucleus Mitochondrion Endoplasmic Reticulum Centrosome Cytosol Kinesin Complex Microtubule Synaptic Vesicle Postsynaptic Density Cell Junction Dynein Complex Ciliary Basal Body Cell Body Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Central Region Of Growth Cone Ciliary Base
	Molecular Function	RNA Binding Actin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding ATPase Activity Cadherin Binding Microtubule Minus-end Binding Actin Filament Binding	Protein Binding Kinesin Binding Protein-containing Complex Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Migration Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Intermediate Filament Cytoskeleton Organization Positive Regulation Of Axon Extension Regulation Of Focal Adhesion Assembly Regulation Of Neuron Projection Arborization	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Cell Proliferation In Forebrain Pyramidal Neuron Migration Positive Regulation Of Wnt Signaling Pathway TOR Signaling Negative Regulation Of Protein Binding Positive Regulation Of Axon Extension Mitochondrial Calcium Ion Homeostasis Response To Electrical Stimulus Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Regulation Of Dendritic Spine Development Protein Localization To Centrosome Regulation Of Synapse Maturation Non-motile Cilium Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Body mass index ( 29273807) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Colorectal cancer ( 27207650) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol ( 25961943 20686565) Headache ( 29397368) Heel bone mineral density ( 30598549) Loneliness (multivariate analysis) ( 27629369) Mean corpuscular hemoglobin concentration ( 27863252) Optic disc size ( 31809533) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Type 2 diabetes ( 27189021 30054458 29358691 30297969 29632382 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382)	Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness index ( 31235810) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483) Neuranatomic and neurocognitive phenotypes ( 21483430) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to antidepressants (symptom improvement) ( 29160301) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536) Waist circumference ( 28552196)
Interacting Genes		27 interacting genes: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DTNBP1 ESRRA EXOC1 GOLGA4 JUN MAPK9 MAPRE1 MTNR1B NRCAM NRXN1 NRXN2 PLXND1 PRKCD SKIL SRPK2 TANGO6 TNIK TRAF3IP1 UBC	107 interacting genes: ACTG1 ACTN2 AGTPBP1 AKAP6 ARIH2 ATF4 ATF5 ATF7IP BICD1 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP126 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FBXW7 FEZ1 FRYL GNB1 GNPTAB GPRASP2 GSK3B HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIF3A KIF3C KIFAP3 MACF1 MAP1A MEMO1 MLLT10 MPPED1 MVP MYH7 MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PCNT PCNX4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI RTRAF SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNKS TRAF3IP1 TRIO TSPOAP1 TUBB TUBB2A UTRN XPNPEP1 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365
Entrez ID		23499	27185
HPRD ID		09750	05553
Ensembl ID		ENSG00000127603	ENSG00000162946
Uniprot IDs		Q6ZSD7 Q9UPN3	C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5
PDB IDs		4Z6G 5VE9 5X57	5V4B
Enriched GO Terms of Interacting Partners?
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