MACF1 and CNTNAP2

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MACF1	CNTNAP2
Description		microtubule actin crosslinking factor 1	contactin associated protein 2
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Actin Cytoskeleton Membrane Ruffle Membrane	Early Endosome Golgi Apparatus Voltage-gated Potassium Channel Complex Cell Surface Membrane Integral Component Of Membrane Axon Dendrite Axolemma Paranodal Junction Neuronal Cell Body Perikaryon Juxtaparanode Region Of Axon
	Molecular Function	RNA Binding Actin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding ATPase Activity Cadherin Binding Microtubule Minus-end Binding Actin Filament Binding	Protein Binding Enzyme Binding
	Biological Process	Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Cell Migration Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Intermediate Filament Cytoskeleton Organization Positive Regulation Of Axon Extension Regulation Of Focal Adhesion Assembly Regulation Of Neuron Projection Arborization	Cell Adhesion Brain Development Learning Neuron Recognition Transmission Of Nerve Impulse Striatum Development Limbic System Development Thalamus Development Cerebral Cortex Development Adult Behavior Neuron Projection Development Social Behavior Vocal Learning Clustering Of Voltage-gated Potassium Channels Neuron Projection Morphogenesis Superior Temporal Gyrus Development Protein Localization To Juxtaparanode Region Of Axon Vocalization Behavior
Pathways
Drugs
Diseases			Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Beard thickness ( 26926045) Body mass index ( 29273807) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Colorectal cancer ( 27207650) Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) HDL cholesterol ( 25961943 20686565) Headache ( 29397368) Heel bone mineral density ( 30598549) Loneliness (multivariate analysis) ( 27629369) Mean corpuscular hemoglobin concentration ( 27863252) Optic disc size ( 31809533) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Type 2 diabetes ( 27189021 30054458 29358691 30297969 29632382 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382)	Age-related hearing impairment ( 24939585) Alzheimer's disease ( 22159054) Alzheimer's disease (late onset) ( 26049409) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimerâ€™s disease and/or vascular dementia (clinical subgroup VaD++) ( 31473137) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Bipolar disorder and schizophrenia ( 20889312) Bitter alcoholic beverage consumption ( 31046077) Blood protein levels ( 30072576 29875488) Body mass index ( 25760438) Body mass index (dietary energy interaction) ( 23192594) Bone mineral density ( 17903296) Choroid plexus volume ( 31530798) Chronic kidney disease (severe chronic kidney disease vs normal kidney function) in type 1 diabetes ( 27647854) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Crohn's disease ( 26192919) Diabetic kidney disease ( 26305897) Family history of Alzheimer's disease ( 30617256) Glaucoma ( 30104761) Inflammatory bowel disease ( 26192919) Initial pursuit acceleration ( 29064472) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol x physical activity interaction (1df test) ( 30670697) LDL cholesterol x physical activity interaction (2df test) ( 30670697) Lung function (FEV1/FVC) ( 30061609) Obesity-related traits ( 23251661) QT interval (drug interaction) ( 23459443) Response to radiotherapy in cancer (late toxicity) ( 24785509) Smoking status (heavy vs never) ( 26423011) Ulcerative colitis ( 26192919) Uterine fibroid size (maximum volume) ( 30196971) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Interacting Genes		27 interacting genes: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DTNBP1 ESRRA EXOC1 GOLGA4 JUN MAPK9 MAPRE1 MTNR1B NRCAM NRXN1 NRXN2 PLXND1 PRKCD SKIL SRPK2 TANGO6 TNIK TRAF3IP1 UBC	8 interacting genes: CASK CNTN2 CTR9 EPB41L3 KCNA2 MACF1 MEOX2 ZMIZ1
Entrez ID		23499	26047
HPRD ID		09750	05197
Ensembl ID		ENSG00000127603	ENSG00000174469
Uniprot IDs		Q6ZSD7 Q9UPN3	A0A090N7T7 B2RCH4 Q9UHC6
PDB IDs		4Z6G 5VE9 5X57	5Y4M
Enriched GO Terms of Interacting Partners?
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