SF3B3 and APBB1

Number of citations of the paper that reports this interaction (PubMedID 16055720)
81

Data Source:
BioGRID (pull down)

		SF3B3	APBB1
Description		splicing factor 3b subunit 3	amyloid beta precursor protein binding family B member 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm U12-type Spliceosomal Complex Nucleolus U2-type Precatalytic Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Speck Lamellipodium Growth Cone Protein-containing Complex Presynaptic Membrane Neuronal Cell Body Dendritic Spine Main Axon Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Growth Cone Lamellipodium Growth Cone Filopodium
	Molecular Function	Nucleic Acid Binding Protein Binding Protein-containing Complex Binding	Amyloid-beta Binding Chromatin Binding Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Histone Binding Protein-containing Complex Binding Tau Protein Binding Proline-rich Region Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing Negative Regulation Of Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Signal Transduction Axonogenesis Response To Iron Ion Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Histone H4 Acetylation Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion Negative Regulation Of Thymidylate Synthase Biosynthetic Process
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs		Quercetin
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321)	Blood protein levels ( 29875488)
Interacting Genes		29 interacting genes: APBB1 EFTUD2 EPS8 ERG HCK HGS HSPB1 KLF10 MPP3 NAGK NOL12 NUTF2 OSGEP PPIL1 PRPF40A RAD9A RBM6 RUFY2 SF3B1 SMAD5 SNRNP200 SREK1 TAF9 TCERG1 TOE1 WBP4 WWOX YWHAG ZNF579	68 interacting genes: ABI1 ABL1 ANXA1 APLP1 APLP2 APP ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRKAR2A PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1
Entrez ID		23450	322
HPRD ID		12027	04087
Ensembl ID		ENSG00000189091	ENSG00000166313
Uniprot IDs		A8K6V3 Q15393	B7Z4M9 O00213
PDB IDs		5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6QX9	2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH
Enriched GO Terms of Interacting Partners?
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