APBB1 and SF3B2

Number of citations of the paper that reports this interaction (PubMedID 16055720)
81

Data Source:
BioGRID (pull down)

		APBB1	SF3B2
Description		amyloid beta precursor protein binding family B member 1	splicing factor 3b subunit 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Plasma Membrane Nuclear Speck Lamellipodium Growth Cone Protein-containing Complex Presynaptic Membrane Neuronal Cell Body Dendritic Spine Main Axon Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Growth Cone Lamellipodium Growth Cone Filopodium	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Amyloid-beta Binding Chromatin Binding Protein Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Histone Binding Protein-containing Complex Binding Tau Protein Binding Proline-rich Region Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Signal Transduction Axonogenesis Response To Iron Ion Positive Regulation Of Neuron Projection Development Negative Regulation Of Cell Growth Positive Regulation Of Apoptotic Process Histone H4 Acetylation Positive Regulation Of DNA Repair Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Secretion Negative Regulation Of Thymidylate Synthase Biosynthetic Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Viral Process
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS		Blood protein levels ( 29875488)	Acne (severe) ( 24927181) Bipolar disorder ( 21926972 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Metabolite levels ( 23823483)
Interacting Genes		68 interacting genes: ABI1 ABL1 ANXA1 APLP1 APLP2 APP ATXN1 ATXN1L CCDC97 CHERP CLSTN1 CPSF6 CPSF7 CYFIP1 CYFIP2 DDX17 DDX3X DDX46 DHX15 DHX9 DIAPH1 DIAPH2 EGFR ELMO1 ENAH ERBB2 EVL FASLG HNRNPH1 HNRNPK HTATSF1 KAT5 KHDRBS1 KHSRP LRP1 LRP2 NONO PABPC1 PQBP1 PRKAR2A PRNP PTBP1 RBM17 RPL4 SF1 SF3A1 SF3A2 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ TFCP2 THRAP3 TSHZ1 TSHZ2 TSHZ3 U2AF2 VASP WAS WASF2 WASL WBP11 WIPF1 WIPF2 YBX1 YLPM1	31 interacting genes: AKAP9 APBB1 APP C7orf25 C8orf33 CASK CSNK2A1 ECPAS ERG FMR1 FRA10AC1 HNRNPC KDM1A LSM2 LSM3 PCBP2 PRC1 PRPF40A RBM10 RBM7 RBM8A SF3B4 SMAD3 SNRNP200 TCERG1 THOC1 TOE1 TOPBP1 TTC14 U2AF1 ZCCHC10
Entrez ID		322	10992
HPRD ID		04087	10410
Ensembl ID		ENSG00000166313	ENSG00000087365
Uniprot IDs		B7Z4M9 O00213	Q13435
PDB IDs		2E45 2HO2 2IDH 2OEI 3D8D 3D8E 3D8F 3DXC 3DXD 3DXE 5NQH	2DO5 5Z56 5Z57 5Z58 6AH0 6FF4 6FF7 6QX9
Enriched GO Terms of Interacting Partners?
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