LSM6 and MCRS1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LSM6	MCRS1
Description		LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated	microspherule protein 1
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm U6 SnRNP Nucleolus Small Nucleolar Ribonucleoprotein Complex Cytoplasm Cytosol Small Nuclear Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Lsm2-8 Complex	Histone Acetyltransferase Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Polysome Dendrite Ino80 Complex Perikaryon NSL Complex MLL1 Complex
	Molecular Function	RNA Binding Protein Binding Protein Heterodimerization Activity	G-quadruplex RNA Binding Protein Binding Poly(U) RNA Binding Poly(G) Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Catabolic Process TRNA Processing RNA Splicing Maturation Of SSU-rRNA Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	DNA Repair DNA Recombination Cellular Protein Modification Process Viral Process Protein Deubiquitination Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Localization To Nucleolus
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway	HATs acetylate histones UCH proteinases DNA Damage Recognition in GG-NER
Drugs		Uridine Uridine monophosphate Citric Acid
Diseases
GWAS		Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		14 interacting genes: APP LSM1 LSM2 LSM3 LSM5 LSM7 LSM8 MCRS1 POLD2 SDCBP SMN1 SNRPD2 SNRPF TARDBP	31 interacting genes: BLM CCDC85B CEP44 DAXX DVL2 FXR2 GCC1 GPBP1 IKZF1 KDM1A KIAA1958 KXD1 LIG4 LSM6 MAGEA11 MED4 NOP2 PBX2 PHC2 PINX1 PRMT5 PTEN RALYL SUV39H1 TERT TRIM37 UPF3B USHBP1 WASHC3 WBP11 ZBTB22
Entrez ID		11157	10445
HPRD ID		06286	11298
Ensembl ID		ENSG00000164167	ENSG00000187778
Uniprot IDs		P62312	A0A024R134 Q96EZ8
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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