ZFPM2 and E2F6

Number of citations of the paper that reports this interaction (PubMedID 23082233)
2

Data Source:
BioGRID (two hybrid)

		ZFPM2	E2F6
Description		zinc finger protein, FOG family member 2	E2F transcription factor 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm MLL1 Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis In Utero Embryonic Development Outflow Tract Septum Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Gonadal Mesoderm Development Heart Development Blood Coagulation Cell Differentiation Lung Development Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Positive Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Negative Regulation Of Cell Death Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Negative Regulation Of G0 To G1 Transition
Pathways		Factors involved in megakaryocyte development and platelet production	G1/S-Specific Transcription Transcriptional Regulation by E2F6
Drugs
Diseases		Tetralogy of Fallot
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Birth weight ( 31043758) Blood protein levels ( 29875488 28240269) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coronary artery calcification ( 23870195) Coronary artery disease ( 29212778) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Glaucoma (primary open-angle) ( 22570617) Impulsivity (attentional) ( 30718321) Mean platelet volume ( 27863252) Metabolite levels ( 23823483) Platelet count ( 26805783 22139419 29403010 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) PR interval ( 30046033) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 28739976) Takayasu arteritis ( 25604533) Tuberculosis ( 24057671) Vascular endothelial growth factor levels ( 26910538 21757650) Venous thromboembolism ( 25772935 28373160 31420334 31676865) White blood cell count (basophil) ( 27863252)	Diisocyanate-induced asthma ( 25918132) Sudden cardiac arrest ( 21658281)
Interacting Genes		11 interacting genes: CTBP1 CTBP2 E2F6 EP300 GATA1 GATA3 GATA4 IL32 ITSN1 STAT3 UBQLN4	28 interacting genes: APP ARAF BMI1 BRDT CENPU DNMT1 DNMT3L DNTTIP1 E2F1 EPC1 EZH1 EZH2 HMG20B INO80B KRTAP10-7 MDN1 NFYA PCGF6 PIK3R3 RING1 RYBP SMARCA4 TFDP1 TFDP2 ZBTB17 ZBTB32 ZFPM2 ZMYND11
Entrez ID		23414	1876
HPRD ID		04737	04251
Ensembl ID		ENSG00000169946	ENSG00000169016
Uniprot IDs		Q8WW38 Q9NPQ0	A0A0S2Z3K8 O75461 Q53YM3 Q6Q9Z5
PDB IDs
Enriched GO Terms of Interacting Partners?
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