ZFPM2 and GATA4

Number of citations of the paper that reports this interaction (PubMedID 11297508)
86

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo, two hybrid, in vitro)

		ZFPM2	GATA4
Description		zinc finger protein, FOG family member 2	GATA binding protein 4
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm	Nuclear Chromatin Cell Nucleus Nucleoplasm Nuclear Body RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Protein Kinase Binding Activating Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding NFAT Protein Binding Co-SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis In Utero Embryonic Development Outflow Tract Septum Morphogenesis Right Ventricular Cardiac Muscle Tissue Morphogenesis Gonadal Mesoderm Development Heart Development Blood Coagulation Cell Differentiation Lung Development Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Positive Regulation Of Cardiac Muscle Cell Proliferation Ventricular Septum Morphogenesis Negative Regulation Of Cell Death Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development	Heart Looping Aortic Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Development Cardiac Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Septum Development Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Regulation Of Transcription, DNA-templated Cell-cell Signaling Endoderm Development Blood Coagulation Male Gonad Development Response To Mechanical Stimulus Negative Regulation Of Autophagy Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of BMP Signaling Pathway Response To Vitamin A Embryonic Heart Tube Anterior/posterior Pattern Specification Response To Drug Cell Fate Commitment Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Foregut Morphogenesis Cardiac Muscle Tissue Development Positive Regulation Of Cardioblast Differentiation Regulation Of Protein Kinase B Signaling Transdifferentiation Atrial Septum Morphogenesis Intestinal Epithelial Cell Differentiation Cardiac Muscle Tissue Regeneration Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Factors involved in megakaryocyte development and platelet production	YAP1- and WWTR1 (TAZ)-stimulated gene expression Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Physiological factors Factors involved in megakaryocyte development and platelet production
Drugs
Diseases		Tetralogy of Fallot	Atrial septal defect
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Birth weight ( 31043758) Blood protein levels ( 29875488 28240269) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coronary artery calcification ( 23870195) Coronary artery disease ( 29212778) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Glaucoma (primary open-angle) ( 22570617) Impulsivity (attentional) ( 30718321) Mean platelet volume ( 27863252) Metabolite levels ( 23823483) Platelet count ( 26805783 22139419 29403010 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) PR interval ( 30046033) Sudden cardiac arrest ( 21658281) Systolic blood pressure ( 28739976) Takayasu arteritis ( 25604533) Tuberculosis ( 24057671) Vascular endothelial growth factor levels ( 26910538 21757650) Venous thromboembolism ( 25772935 28373160 31420334 31676865) White blood cell count (basophil) ( 27863252)	Adventurousness ( 30643258) Atrial fibrillation ( 30061737 29892015) Diastolic blood pressure ( 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Myopia (pathological) ( 23049088) Polycystic ovary syndrome ( 26284813) Retinal vascular caliber ( 21060863) Systolic blood pressure ( 28135244 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Testicular germ cell tumor ( 28604728)
Interacting Genes		11 interacting genes: CTBP1 CTBP2 E2F6 EP300 GATA1 GATA3 GATA4 IL32 ITSN1 STAT3 UBQLN4	24 interacting genes: ALX4 CRIP2 EP300 FOS HAND2 ID1 ID2 ID3 JARID2 MAPK1 MAPK3 MDC1 MED1 MEF2C NFATC4 NKX2-5 NR5A1 PIAS1 RACK1 SP1 SRF TBX5 ZBTB3 ZFPM2
Entrez ID		23414	2626
HPRD ID		04737	08994
Ensembl ID		ENSG00000169946	ENSG00000136574
Uniprot IDs		Q8WW38 Q9NPQ0	B3KUF4 B6DU75 P43694
PDB IDs			2M9W
Enriched GO Terms of Interacting Partners?
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