SPECC1L and GLIS2

Number of citations of the paper that reports this interaction (PubMedID 17289029)
23

Data Source:
BioGRID (two hybrid)

		SPECC1L	GLIS2
Description		sperm antigen with calponin homology and coiled-coil domains 1 like	GLIS family zinc finger 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Microtubule Organizing Center Spindle Cytosol Gap Junction Actin Cytoskeleton Filamentous Actin	Nucleus Cytoplasm Nuclear Speck Non-motile Cilium
	Molecular Function		RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Cell Cycle Cell Adhesion Actin Cytoskeleton Organization Cell Division	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter Involved In Kidney Development Cell Differentiation Involved In Kidney Development Positive Regulation Of Protein Localization To Nucleus
Pathways
Drugs
Diseases			Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Acne (severe) ( 24927181 30542056) Coronary artery disease ( 29212778) Severity of nausea and vomiting of pregnancy ( 29563502)	Erectile dysfunction ( 30583798) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 26635082) Prostate-specific antigen levels ( 28139693)
Interacting Genes		5 interacting genes: APC ECPAS GLIS2 UBC UBE2I	49 interacting genes: AKT1 ARAF ARNT BCAR1 BECN1 CBLC CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CPSF1 CTNNB1 EPHA2 ERBB2 FGFR4 FZR1 GLIS1 GPSM2 HGF HIF1A LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MDM2 MDM4 MET MYC NF2 NFIC NSD3 PIK3CA RAF1 RASSF1 RBFOX2 SOX3 SPECC1L STK11 TEAD2 TERT TRIM32 U2AF2 WNK1 WT1 XAB2
Entrez ID		23384	84662
HPRD ID		11080	12256
Ensembl ID		ENSG00000100014	ENSG00000126603
Uniprot IDs		B2RMV2 Q69YQ0	B3KTH4 Q9BZE0
PDB IDs
Enriched GO Terms of Interacting Partners?
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