SRGAP2 and EXOC1

Number of citations of the paper that reports this interaction (PubMedID 17043677)
168

Data Source:
BioGRID (two hybrid)

		SRGAP2	EXOC1
Description		SLIT-ROBO Rho GTPase activating protein 2	exocyst complex component 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Lamellipodium Cell Junction Dendritic Spine Head Postsynaptic Membrane Phagocytic Vesicle	Exocyst Cytoplasm Cytosol Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Flemming Body Cytoplasmic Side Of Apical Plasma Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Rac GTPase Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding GTP-Rho Binding
	Biological Process	Lamellipodium Assembly Involved In Ameboidal Cell Migration Signal Transduction Extension Of A Leading Process Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Migration Substrate Adhesion-dependent Cell Spreading Positive Regulation Of GTPase Activity Filopodium Assembly Neuron Projection Morphogenesis Actin Filament Severing Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Cell Death Dendritic Spine Development Negative Regulation Of Neuron Migration	Exocytosis Golgi To Plasma Membrane Transport Protein Transport Viral Process Regulation Of Macroautophagy Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Secretion Exocyst Localization Defense Response To Virus
Pathways		Rho GTPase cycle Inactivation of CDC42 and RAC1 RHO GTPases Activate Formins	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Cholesterol and Triglycerides ( 23031429) Type 2 diabetes ( 30297969)	Cerebrospinal P-tau181p levels ( 28247064) Cervical cancer ( 23817570) Daytime sleep phenotypes ( 27126917) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: DISC1 EXOC1 FASLG ROBO1 YWHAG	27 interacting genes: ATG14 CCDC88A CCDC93 CCSER2 CDC5L CEP295 COLEC12 DISC1 DST KANSL1 KDM1A LUC7L2 MACF1 MTNR1A NUF2 RALA RB1CC1 RESF1 RUBCN SFR1 SH3BP5 SPTAN1 SRGAP2 SYBU TRAF3IP1 TRIM9 TRIO
Entrez ID		23380	55763
HPRD ID		18520	07615
Ensembl ID		ENSG00000266028	ENSG00000090989
Uniprot IDs		A0A075B7B5 B4DFE5 B7Z3G4 B7ZM87 O75044	A0A024RDA1 A1LT29 Q9NV70
PDB IDs		2DL8 4RTT 4RUG 5I6J 5I6R 5I7D
Enriched GO Terms of Interacting Partners?
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