EXOC1 and NUF2

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		EXOC1	NUF2
Description		exocyst complex component 1	NUF2 component of NDC80 kinetochore complex
Image		No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Cytosol Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Flemming Body Cytoplasmic Side Of Apical Plasma Membrane	Chromosome, Centromeric Region Condensed Nuclear Chromosome Kinetochore Cell Nucleoplasm Cytosol Membrane Ndc80 Complex
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding GTP-Rho Binding	Molecular_function Protein Binding Protein-containing Complex Binding
	Biological Process	Exocytosis Golgi To Plasma Membrane Transport Protein Transport Viral Process Regulation Of Macroautophagy Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Secretion Exocyst Localization Defense Response To Virus	Mitotic Spindle Organization Chromosome Segregation Meiotic Chromosome Segregation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Cerebrospinal P-tau181p levels ( 28247064) Cervical cancer ( 23817570) Daytime sleep phenotypes ( 27126917) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Asthma ( 29273806) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Diffusing capacity of carbon monoxide ( 30694715) Height ( 28552196) Myopia ( 27182965)
Interacting Genes		27 interacting genes: ATG14 CCDC88A CCDC93 CCSER2 CDC5L CEP295 COLEC12 DISC1 DST KANSL1 KDM1A LUC7L2 MACF1 MTNR1A NUF2 RALA RB1CC1 RESF1 RUBCN SFR1 SH3BP5 SPTAN1 SRGAP2 SYBU TRAF3IP1 TRIM9 TRIO	10 interacting genes: ATF3 AURKA AURKB AZGP1 CENPE CENPH DTNBP1 EXOC1 NDC80 SDCBP2
Entrez ID		55763	83540
HPRD ID		07615	10817
Ensembl ID		ENSG00000090989	ENSG00000143228
Uniprot IDs		A0A024RDA1 A1LT29 Q9NV70	Q9BZD4
PDB IDs			2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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