FLNC and TRIM54

Number of citations of the paper that reports this interaction (PubMedID 17360532)
37

Data Source:
BioGRID (two hybrid)

		FLNC	TRIM54
Description		filamin C	tripartite motif containing 54
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Sarcoplasm Z Disc Sarcolemma Costamere	Microtubule Microtubule Associated Complex Z Disc
	Molecular Function	Actin Binding Protein Binding Cytoskeletal Protein Binding Ankyrin Binding	Protein Binding Microtubule Binding Zinc Ion Binding
	Biological Process	Cell Junction Assembly Muscle Fiber Development	Microtubule-based Process Negative Regulation Of Microtubule Depolymerization Signal Transduction Multicellular Organism Development Cell Differentiation
Pathways		Cell-extracellular matrix interactions
Drugs
Diseases		Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy
GWAS		Reading disability or specific language impairment (pleiotropy) ( 25065397) Reading disability or specific language impairment adjusted for intelligence quotient (pleiotropy) ( 25065397)
Interacting Genes		31 interacting genes: ADRA1A ADRA1B ADRA1D CAPN3 FURIN HIPK3 HSPB2 INPPL1 KCND2 KY MAP2K4 MTDH MYOT MYOZ1 MYOZ2 MYOZ3 NPHP1 PHLDB2 PRKAB2 PRKCA RPS6KA2 SGCD SGCG SYNPO2 TRIM54 TRIM55 TRIM63 USP25 WNK1 XIRP1 XIRP2	132 interacting genes: ADCY4 ARFIP2 ARHGEF5 ATXN3 ATXN3L ATXN7 BYSL C12orf49 C1orf109 C1orf216 C1QTNF2 C2CD6 CALM3 CARD9 CCDC102B CCDC146 CCDC28A CCDC87 CDK18 CDKN1A CENPX CEP57L1 CHCHD2 CKM CRADD CWF19L2 CYTH4 DCUN1D1 DEUP1 DNAL4 DTX2 EHHADH EIF4E2 ELMO1 ELOA ENKD1 EPM2AIP1 EXOSC5 FAM110A FAM124A FAM124B FAM161A FARS2 FBF1 FLNC GEM GMCL1 GTF2IRD2 HAUS1 HSPB1 ING3 INPP5J IQUB JOSD1 KDM1A KIFC3 KLHL38 KPNA2 KRT6A KRT6B KRT6C LENG1 LIN37 LMO2 LNX1 LSM2 MAPK3 MBD3 MCM7 MEAF6 MFAP1 MID2 MYO5B NGLY1 NTAQ1 OSTF1 OTUB1 OTUB2 PIK3R3 PPP1R18 PRF1 RABGEF1 RAD23A RBM41 RCOR3 RSRC2 SCNM1 SDCBP SENP3 SH2D1B SMARCE1 SNF8 SPG21 SSX2IP STAM TBC1D22B TCEA2 THOC1 TRIM55 TRIM63 TSHZ3 TTC23 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 USHBP1 USP15 USP18 USP2 USP21 USP33 USP4 USP5 USP7 USP8 UTP14C VPS28 WDR34 YOD1 ZBTB16 ZGPAT ZNF250 ZNF417 ZNF572 ZNF587
Entrez ID		2318	57159
HPRD ID		00018	05928
Ensembl ID		ENSG00000128591	ENSG00000138100
Uniprot IDs		Q14315 Q59H94	Q9BYV2
PDB IDs		1V05 2D7M 2D7N 2D7O 2D7P 2D7Q 2K9U 2NQC 3V8O 4MGX	3Q1D
Enriched GO Terms of Interacting Partners?
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