P2RX2 and GABRR1

Number of citations of the paper that reports this interaction (PubMedID 14660627)
19

Data Source:
HPRD (in vivo, in vitro)

		P2RX2	GABRR1
Description		purinergic receptor P2X 2	gamma-aminobutyric acid type A receptor subunit rho1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Integral Component Of Nuclear Inner Membrane Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane Neuronal Cell Body Receptor Complex Postsynapse	Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Chloride Channel Complex Neuron Projection Synapse Postsynaptic Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity ATP Binding Ligand-gated Ion Channel Activity Identical Protein Binding	GABA-A Receptor Activity Chloride Channel Activity Ligand-gated Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Response To Hypoxia Response To Ischemia Detection Of Hypoxic Conditions In Blood By Carotid Body Chemoreceptor Signaling Neuromuscular Synaptic Transmission Neuromuscular Junction Development Blood Coagulation Sensory Perception Of Sound Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Peristalsis Response To ATP Purinergic Nucleotide Receptor Signaling Pathway Behavioral Response To Pain Skeletal Muscle Fiber Development Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Excitatory Postsynaptic Potential Cation Transmembrane Transport	Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Ion Transmembrane Transport Regulation Of Membrane Potential Nervous System Process Regulation Of Postsynaptic Membrane Potential Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis	GABA receptor activation
Drugs			Temazepam Lindane Picrotoxin Adinazolam Midazolam Flurazepam Halazepam Diazepam Oxazepam Triazolam Estazolam Bromazepam Clotiazepam Fludiazepam Prazepam Quazepam Cinolazepam Nitrazepam
Diseases
GWAS		Body mass index ( 26426971)	Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Bipolar disorder and schizophrenia ( 20889312) Diabetic kidney disease in type 2 diabetes ( 29703844) Early diabetic kidney disease in type 2 diabetes ( 29703844) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472)
Interacting Genes		3 interacting genes: GABRR1 P2RX1 P2RX3	10 interacting genes: CSNK2A1 GABRR2 MAP1B MAPK1 P2RX2 PRKACA PRKCA PRKG1 SLC6A9 SQSTM1
Entrez ID		22953	2569
HPRD ID		15984	15921
Ensembl ID		ENSG00000187848	ENSG00000146276
Uniprot IDs		Q32MC3 Q9UBL9	P24046
PDB IDs
Enriched GO Terms of Interacting Partners?
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