R3HDM2 and SPRY1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		R3HDM2	SPRY1
Description		R3H domain containing 2	sprouty RTK signaling antagonist 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Cell Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	RNA Binding	Protein Binding
	Biological Process		Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Negative Regulation Of Cell Proliferation Negative Regulation Of GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of ERK1 And ERK2 Cascade
Pathways			EGFR downregulation
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488) Blood urea nitrogen levels ( 31152163) Body mass index ( 28552196) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163 31015462) Glomerular filtration rate (creatinine) ( 28452372) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Schizophrenia ( 25056061 29483656) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Urate levels ( 20884846 31578528) Urate levels in overweight individuals ( 25811787)	Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Irritable bowel syndrome ( 24797007) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Pelvic organ prolapse ( 26545240) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858)
Interacting Genes		10 interacting genes: ATXN1 C1orf94 FAM168A KRTAP10-3 KRTAP10-8 KRTAP3-2 NOTCH2NLA RBPMS REL SPRY1	27 interacting genes: ATXN7 CACNA1A CREB5 GEMIN4 GRB2 HEXIM2 HOXA1 HRG KPNA2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 LCE1B LCE2D MDFI MEOX2 NOTCH2NLA OTX1 R3HDM2 SOCS4 SPRY2 STAT3 YY1
Entrez ID		22864	10252
HPRD ID		13827	06782
Ensembl ID		ENSG00000179912	ENSG00000164056
Uniprot IDs		A0A0U1RRA6 B5MCG9 Q9Y2K5	O43609
PDB IDs		1WHR
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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