NLRP1 and NOD1

Number of citations of the paper that reports this interaction (PubMedID 11113115)
44

Data Source:
HPRD (in vitro)

		NLRP1	NOD1
Description		NLR family pyrin domain containing 1	nucleotide binding oligomerization domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Inflammasome Complex NLRP1 Inflammasome Complex	Cytoplasm Cytosol Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Domain Specific Binding	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Protein Homodimerization Activity Peptidoglycan Binding Protein-containing Complex Binding CARD Domain Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Viral Process Response To Muramyl Dipeptide Defense Response To Bacterium Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Neuron Apoptotic Process NLRP1 Inflammasome Complex Assembly	Activation Of MAPK Activity Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Detection Of Biotic Stimulus Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Interleukin-8 Biosynthetic Process Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Muramyl Dipeptide Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Xenophagy
Pathways		The NLRP1 inflammasome	NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling
Drugs
Diseases
GWAS		Migraine ( 27322543)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Knee osteoarthritis ( 27696742)
Interacting Genes		9 interacting genes: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 NOD1 PYCARD	13 interacting genes: ATG16L1 CARD6 CASP1 CASP2 CASP4 CASP8 CASP9 GABRB1 NLRP1 RIPK2 RNF34 SOX8 XIAP
Entrez ID		22861	10392
HPRD ID		07364	05815
Ensembl ID		ENSG00000091592	ENSG00000106100
Uniprot IDs		Q9C000	A0A024RA73 G3XAL1 Q9Y239
PDB IDs		1PN5 3KAT 4IFP 4IM6 5Y3S	2B1W 2DBD 2NSN 2NZ7 4E9M 4JQW
Enriched GO Terms of Interacting Partners?
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