NOD1 and ATG16L1

Number of citations of the paper that reports this interaction (PubMedID 19898471)
451

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		NOD1	ATG16L1
Description		nucleotide binding oligomerization domain containing 1	autophagy related 16 like 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Basolateral Plasma Membrane Apical Plasma Membrane	Autophagosome Membrane Autophagosome Cytosol Axoneme Phagophore Assembly Site Membrane
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Protein Homodimerization Activity Peptidoglycan Binding Protein-containing Complex Binding CARD Domain Binding	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding GTPase Binding
	Biological Process	Activation Of MAPK Activity Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Detection Of Biotic Stimulus Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Interleukin-8 Biosynthetic Process Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Muramyl Dipeptide Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Xenophagy	Autophagosome Assembly Protein Transport Macroautophagy Negative Stranded Viral RNA Replication
Pathways		NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling	Macroautophagy Macroautophagy
Drugs
Diseases			Crohn's disease
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Knee osteoarthritis ( 27696742)	Bilirubin levels ( 31319653) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17435756 17554300 21102463 23128233) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		13 interacting genes: ATG16L1 CARD6 CASP1 CASP2 CASP4 CASP8 CASP9 GABRB1 NLRP1 RIPK2 RNF34 SOX8 XIAP	16 interacting genes: APP ATG12 ATG5 C3 CSNK2A1 CSNK2A2 GAN GIGYF2 NOD1 OPTN PLD3 RAB33A RAB33B SCAP TMEM59 UBC
Entrez ID		10392	55054
HPRD ID		05815	16498
Ensembl ID		ENSG00000106100	ENSG00000085978
Uniprot IDs		A0A024RA73 G3XAL1 Q9Y239	A0A024R494 A0A024R4B6 Q17RG0 Q53SV2 Q676U5
PDB IDs		2B1W 2DBD 2NSN 2NZ7 4E9M 4JQW	4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX
Enriched GO Terms of Interacting Partners?
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