NOD1

Description		nucleotide binding oligomerization domain containing 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Identical Protein Binding Protein Homodimerization Activity Peptidoglycan Binding Protein-containing Complex Binding CARD Domain Binding
	Biological Process	Activation Of MAPK Activity Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Defense Response Inflammatory Response Signal Transduction JNK Cascade Detection Of Biotic Stimulus Detection Of Bacterium Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Interleukin-8 Biosynthetic Process Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of JNK Cascade Defense Response To Gram-positive Bacterium Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Muramyl Dipeptide Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Xenophagy
Pathways		NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling
Drugs
Diseases
GWAS		Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Knee osteoarthritis ( 27696742)
Interacting Genes		13 interacting genes: ATG16L1 CARD6 CASP1 CASP2 CASP4 CASP8 CASP9 GABRB1 NLRP1 RIPK2 RNF34 SOX8 XIAP
Entrez ID		10392
HPRD ID		05815
Ensembl ID		ENSG00000106100
Uniprot IDs		A0A024RA73 G3XAL1 Q9Y239
PDB IDs		2B1W 2DBD 2NSN 2NZ7 4E9M 4JQW
Enriched GO Terms of Interacting Partners?
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