RRAS2 and RASGRF1

Number of citations of the paper that reports this interaction (PubMedID 12384139)
48

Data Source:
HPRD (in vitro)

		RRAS2	RASGRF1
Description		RAS related 2	Ras protein specific guanine nucleotide releasing factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Membrane Extracellular Exosome	Cytosol Plasma Membrane Growth Cone Neuron Projection
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding
	Biological Process	Osteoblast Differentiation Ras Protein Signal Transduction Positive Regulation Of Cell Migration Regulation Of Neuron Death	MAPK Cascade Signal Transduction Small GTPase Mediated Signal Transduction Long-term Memory Cell Proliferation Neuron Projection Development Response To Endoplasmic Reticulum Stress Regulation Of Rac Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Activation Of GTPase Activity Regulation Of NMDA Receptor Activity
Pathways			Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Height ( 31562340) Mitochondrial DNA levels ( 25240745) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244) Vitamin D levels ( 25208829)	Bronchopulmonary dysplasia ( 23897914) Hand grip strength ( 29691431) Myopia ( 27182965) Refractive error ( 23396134 20835236) RR interval (heart rate) ( 20031603) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		29 interacting genes: ACVR1 AFDN AHSG ARAF ARHGEF2 BMPR1B CREB3 FNTB LGALS4 PAWR PGGT1B PIK3R1 PTPN1 RABAC1 RAF1 RALGDS RAPGEF1 RAPGEF3 RAPGEF4 RASGRF1 RASIP1 RASSF5 RIN1 SMAD3 SMAD4 SMURF2 TRAF2 TRAF3 XRCC6	18 interacting genes: CEBPA EHD4 GRK2 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 SRC SRPK2 TNK2 USP8 YWHAB YWHAE
Entrez ID		22800	5923
HPRD ID		02518	07362
Ensembl ID		ENSG00000133818	ENSG00000058335
Uniprot IDs		P62070	A8K270 Q13972 Q8IUU5
PDB IDs		2ERY
Enriched GO Terms of Interacting Partners?
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