RASGRF1 and EHD4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		RASGRF1	EHD4
Description		Ras protein specific guanine nucleotide releasing factor 1	EH domain containing 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Growth Cone Neuron Projection	Nucleus Endoplasmic Reticulum Plasma Membrane Membrane Early Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Glutamate Receptor Binding	Nucleic Acid Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Cadherin Binding
	Biological Process	MAPK Cascade Signal Transduction Small GTPase Mediated Signal Transduction Long-term Memory Cell Proliferation Neuron Projection Development Response To Endoplasmic Reticulum Stress Regulation Of Rac Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of Ras Protein Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Activation Of GTPase Activity Regulation Of NMDA Receptor Activity	Pinocytosis Regulation Of Endocytosis Endocytic Recycling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Homooligomerization Cellular Response To Growth Factor Stimulus
Pathways		Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Bronchopulmonary dysplasia ( 23897914) Hand grip strength ( 29691431) Myopia ( 27182965) Refractive error ( 23396134 20835236) RR interval (heart rate) ( 20031603) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Adverse response to drug ( 30420678) Granulocyte count ( 27863252) Heel bone mineral density ( 30598549) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 29403010 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Platelet count ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		18 interacting genes: CEBPA EHD4 GRK2 HRAS NTRK1 NTRK2 NTRK3 PRKACA RAC1 RHOA RRAS2 SNRNP70 SRC SRPK2 TNK2 USP8 YWHAB YWHAE	2 interacting genes: AFP RASGRF1
Entrez ID		5923	30844
HPRD ID		07362	10435
Ensembl ID		ENSG00000058335	ENSG00000103966
Uniprot IDs		A8K270 Q13972 Q8IUU5	A0A024R9N6 A8K9B9 Q9H223
PDB IDs
Enriched GO Terms of Interacting Partners?
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