FBN2 and NRG2

		FBN2	NRG2
Description		fibrillin 2	neuregulin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity	Signaling Receptor Binding Growth Factor Activity
	Biological Process	Anatomical Structure Morphogenesis Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation	MAPK Cascade Signal Transduction Nervous System Development Intracellular Signal Transduction ERBB2 Signaling Pathway Animal Organ Development Positive Regulation Of Protein Kinase B Signaling Regulation Of Cell Motility
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Signaling by ERBB2 Signaling by ERBB4 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants
Drugs		Calcium Citrate Calcium Phosphate
Diseases		Congenital contractural arachnodactyly (CCA) ; Beals syndrome
GWAS		Atrial fibrillation ( 29892015) Beard thickness ( 26926045) Breastfeeding duration ( 25475840) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Height ( 21998595 31562340) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 29617998) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multiple system atrophy ( 27629089) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 19553259) Pulse pressure ( 27841878 30578418) Response to fenofibrate (total cholesterol levels) ( 27002377) Severe aplastic anemia ( 32004448) Systolic blood pressure ( 28135244 27841878 30578418) Temperament ( 22832960)	Body mass index ( 26426971) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980)
Interacting Genes		22 interacting genes: CMBL CSF2 DPYSL5 DUSP5 ELN FBN1 FDPS ITGA2 LTBP1 MATN2 MFAP2 MFAP5 NDUFB6 NRG2 RNF14 SEMA3F SIRPA SLC27A6 SMAD2 SNRPB TRIM24 UBE2B	3 interacting genes: ERBB3 ERBB4 FBN2
Entrez ID		2201	9542
HPRD ID		00416	04821
Ensembl ID		ENSG00000138829	ENSG00000158458
Uniprot IDs		P35556	F5GZS7 O14511
PDB IDs
Enriched GO Terms of Interacting Partners?
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