FBN2 and DUSP5

		FBN2	DUSP5
Description		fibrillin 2	dual specificity phosphatase 5
Image		No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Matrix Collagen-containing Extracellular Matrix	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity	Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Anatomical Structure Morphogenesis Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation	MAPK Cascade Activation Of MAPK Activity Inactivation Of MAPK Activity Endoderm Formation Protein Dephosphorylation Dephosphorylation Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway
Drugs		Calcium Citrate Calcium Phosphate
Diseases		Congenital contractural arachnodactyly (CCA) ; Beals syndrome
GWAS		Atrial fibrillation ( 29892015) Beard thickness ( 26926045) Breastfeeding duration ( 25475840) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Height ( 21998595 31562340) Heschl's gyrus morphology ( 25130324) Intraocular pressure ( 29617998) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Multiple system atrophy ( 27629089) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 19553259) Pulse pressure ( 27841878 30578418) Response to fenofibrate (total cholesterol levels) ( 27002377) Severe aplastic anemia ( 32004448) Systolic blood pressure ( 28135244 27841878 30578418) Temperament ( 22832960)	Crohn's disease ( 23850713) Heel bone mineral density ( 30598549) Lumbar spine bone mineral density (integral) ( 27476799) Non-albumin protein levels ( 29403010) Total body bone mineral density ( 29304378)
Interacting Genes		22 interacting genes: CMBL CSF2 DPYSL5 DUSP5 ELN FBN1 FDPS ITGA2 LTBP1 MATN2 MFAP2 MFAP5 NDUFB6 NRG2 RNF14 SEMA3F SIRPA SLC27A6 SMAD2 SNRPB TRIM24 UBE2B	5 interacting genes: AATK FBN2 MAPK1 MAPK3 MTDH
Entrez ID		2201	1847
HPRD ID		00416	04349
Ensembl ID		ENSG00000138829	ENSG00000138166
Uniprot IDs		P35556	Q16690
PDB IDs			2G6Z
Enriched GO Terms of Interacting Partners?
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