EYA3 and SIX4

Number of citations of the paper that reports this interaction (PubMedID 10490620)
89

Data Source:
HPRD (in vitro)

		EYA3	SIX4
Description		EYA transcriptional coactivator and phosphatase 3	SIX homeobox 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome	Nuclear Chromatin Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
	Biological Process	Double-strand Break Repair Multicellular Organism Development Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Histone Dephosphorylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair Anatomical Structure Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Skeletal Muscle Tissue Development Regulation Of Synaptic Growth At Neuromuscular Junction Male Gonad Development Anatomical Structure Morphogenesis Male Sex Determination Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Tongue Development Sarcomere Organization Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Male Sex Differentiation Thymus Development Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Anatomical Structure Development Regulation Of Epithelial Cell Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Skeletal Muscle Fiber Differentiation Negative Regulation Of Satellite Cell Differentiation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Plasma trimethylamine N-oxide levels ( 28439531) Total cholesterol levels ( 30275531)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Height ( 31562340)
Interacting Genes		7 interacting genes: CRK DACH1 SIX1 SIX2 SIX4 SIX5 ZDHHC17	2 interacting genes: EYA2 EYA3
Entrez ID		2140	51804
HPRD ID		09042	06960
Ensembl ID		ENSG00000158161	ENSG00000100625
Uniprot IDs		Q99504	Q9UIU6
PDB IDs
Enriched GO Terms of Interacting Partners?
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