EYA3 and SIX1

Number of citations of the paper that reports this interaction (PubMedID 12215533)
52

Data Source:
HPRD (in vitro)

		EYA3	SIX1
Description		EYA transcriptional coactivator and phosphatase 3	SIX homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Centrosome	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Double-strand Break Repair Multicellular Organism Development Visual Perception Anatomical Structure Morphogenesis Response To Ionizing Radiation Histone Dephosphorylation Cell Differentiation Peptidyl-tyrosine Dephosphorylation Positive Regulation Of DNA Repair Anatomical Structure Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Organ Induction Kidney Development Outflow Tract Morphogenesis Regulation Of Transcription, DNA-templated Apoptotic Process Pattern Specification Process Skeletal Muscle Tissue Development Sensory Perception Of Sound Regulation Of Synaptic Growth At Neuromuscular Junction Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Skeletal Muscle Cell Proliferation Facial Nerve Morphogenesis Epithelial Cell Differentiation Thyroid Gland Development Olfactory Placode Formation Regulation Of Protein Localization Protein Localization To Nucleus Aorta Morphogenesis Inner Ear Morphogenesis Middle Ear Morphogenesis Negative Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Neuron Fate Specification Generation Of Neurons Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Skeletal Muscle Fiber Development Inner Ear Development Anatomical Structure Development Regulation Of Epithelial Cell Proliferation Myoblast Migration Pharyngeal System Development Myotome Development Fungiform Papilla Morphogenesis Trigeminal Ganglion Development Otic Vesicle Development Metanephric Mesenchyme Development Regulation Of Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of Ureteric Bud Formation Mesonephric Tubule Formation Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Secondary Heart Field Cardioblast Proliferation Cochlea Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Brown Fat Cell Differentiation Cellular Response To 3,3',5-triiodo-L-thyronine Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases			Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
GWAS		Plasma trimethylamine N-oxide levels ( 28439531) Total cholesterol levels ( 30275531)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Glaucoma ( 31959993) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 22419738 29891935 22570617) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31562340) Optic disc size ( 31809533) Optic nerve measurement (rim area) ( 20395239) Prostate cancer ( 25217961) Vertical cup-disc ratio ( 20548946 25241763)
Interacting Genes		7 interacting genes: CRK DACH1 SIX1 SIX2 SIX4 SIX5 ZDHHC17	10 interacting genes: CCDC85B DACH1 EYA1 EYA2 EYA3 EYA4 MDFI TLE1 TLE5 VTN
Entrez ID		2140	6495
HPRD ID		09042	03125
Ensembl ID		ENSG00000158161	ENSG00000126778
Uniprot IDs		Q99504	Q15475
PDB IDs			4EGC
Enriched GO Terms of Interacting Partners?
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