ESRRA and ESRRG

Number of citations of the paper that reports this interaction (PubMedID 15604093)
54

Data Source:
HPRD (two hybrid)

		ESRRA	ESRRG
Description		estrogen related receptor alpha	estrogen related receptor gamma
Image
GO Annotations	Cellular Component	Nuclear Chromatin Fibrillar Center Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Intercellular Bridge	Nuclear Chromatin Nucleoplasm
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Sequence-specific DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding AF-2 Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Mitochondrion Organization Intracellular Receptor Signaling Pathway Response To Estradiol Regulation Of Cell Proliferation Steroid Hormone Mediated Signaling Pathway Regulation Of Osteoblast Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Positive Regulation Of Cellular Response To Insulin Stimulus	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity	Nuclear Receptor transcription pathway
Drugs		Troglitazone Diethylstilbestrol Genistein Afimoxifene beta-Naphthoflavone 1-CYCLOHEXYL-N-{[1-(4-METHYLPHENYL)-1H-INDOL-3-YL]METHYL}METHANAMINE Flavone	Troglitazone Diethylstilbestrol Tamoxifen Estradiol Cholic Acid Afimoxifene 4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE 4-(1-methyl-1-phenylethyl)phenol 4,4'-PROPANE-2,2-DIYLDIPHENOL 4,4'-cyclohexane-1,1-diyldiphenol
Diseases
GWAS		Crohn's disease ( 28067908 21102463) Vitiligo ( 27723757)	Adventurousness ( 30643258) Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Adverse response to drug ( 30420678) Alcohol consumption ( 23743675) Breast cancer ( 29059683) Cardiac hypertrophy ( 21348951) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Depressive symptom (anhedonia) (ordinal trait) ( 31530331) Dialysis-related mortality ( 21546767) Energy expenditure (24h) ( 28476931) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Intelligence (MTAG) ( 29326435) Intracranial aneurysm ( 29531279) Major depressive disorder ( 23377640) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Optic nerve measurement (cup area) ( 20395239) Photic sneeze reflex ( 27182965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Sleep duration ( 25469926) Smoking status (ever vs never smokers) ( 30643258) Tea consumption ( 31046077) Weight ( 28552196)
Interacting Genes		31 interacting genes: ADH5 ATXN1 DUT ESR1 ESRRG EXOSC6 FUS GTF2B HDAC8 HIF1A KAT2B LYST MACF1 MAP2K5 NCOA1 NCOA3 NR0B1 NR0B2 NRIP1 NSD1 NXF1 PIAS4 PNRC2 PPARGC1A PRKCD PROX1 PSMC5 SIRT1 SMARCD3 SP1 TNNI2	32 interacting genes: APP ARHGEF15 CALM1 DAXX DEUP1 DUT EBP ESRRA HGS HIF1A KIFC3 LRRK2 MARK1 MEOX2 MFHAS1 NCOA1 NR0B1 NR0B2 NRIP1 NUP160 PNRC1 PNRC2 PPARGC1A PPARGC1B PROX1 PSMC5 SHTN1 SP1 SRA1 SRPK1 SUMO1P1 TLE1
Entrez ID		2101	2104
HPRD ID		07210	04274
Ensembl ID		ENSG00000173153	ENSG00000196482
Uniprot IDs		P11474 Q569H8	B7Z5E9 C0SQ93 F1D8R5 F1D8R6 P62508
PDB IDs		1XB7 2PJL 3D24 3K6P	1KV6 1TFC 1VJB 2E2R 2EWP 2GP7 2GPO 2GPP 2GPU 2GPV 2P7A 2P7G 2P7Z 2ZAS 2ZBS 2ZKC 5YSO 6A6K 6I61 6I62 6I63 6I64 6I65 6I66 6I67
Enriched GO Terms of Interacting Partners?
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