EPOR and KIT

Number of citations of the paper that reports this interaction (PubMedID 11124255)
10

Data Source:
HPRD (in vivo)

		EPOR	KIT
Description		erythropoietin receptor	KIT proto-oncogene, receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck	Fibrillar Center Acrosomal Vesicle Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Mast Cell Granule Receptor Complex
	Molecular Function	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding	Protease Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Stem Cell Factor Receptor Activity Protein Binding ATP Binding Growth Factor Binding Cytokine Binding SH2 Domain Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Signal Transduction Brain Development Heart Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Erythropoietin-mediated Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Decidualization	MAPK Cascade Activation Of MAPK Activity Ovarian Follicle Development Hematopoietic Progenitor Cell Differentiation Myeloid Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Dendritic Cell Cytokine Production Mast Cell Chemotaxis Regulation Of Transcription By RNA Polymerase II Glycosphingolipid Metabolic Process Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Spermatogenesis Spermatid Development Positive Regulation Of Cell Proliferation Germ Cell Migration Regulation Of Cell Shape Visual Learning Male Gonad Development Positive Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Stem Cell Population Maintenance Lamellipodium Assembly Hemopoiesis B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Melanocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Actin Cytoskeleton Reorganization Mast Cell Cytokine Production Positive Regulation Of Kinase Activity Somatic Stem Cell Population Maintenance Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Hematopoietic Stem Cell Migration Megakaryocyte Development Fc Receptor Signaling Pathway Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Programmed Cell Death Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Tongue Development Positive Regulation Of Notch Signaling Pathway Positive Regulation Of JAK-STAT Cascade Response To Cadmium Ion Protein Autophosphorylation Somatic Stem Cell Division Positive Regulation Of Long-term Neuronal Synaptic Plasticity Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Mast Cell Differentiation Mast Cell Proliferation Cellular Response To Thyroid Hormone Stimulus Melanocyte Migration Melanocyte Adhesion Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Regulation Of Bile Acid Metabolic Process Positive Regulation Of Colon Smooth Muscle Contraction Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Vascular Smooth Muscle Cell Differentiation
Pathways		Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS	PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Regulation of KIT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Drugs		Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta	Sorafenib Imatinib Dasatinib Sunitinib Phosphonotyrosine Nilotinib XL820 OSI-930 ABT-869 Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Amuvatinib
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)	Piebaldism Acute myeloid leukemia (AML)
GWAS		Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)	Anorexia nervosa or obsessive-compulsive disorder ( 30087453) Bipolar disorder ( 19416921) Breastfeeding duration ( 25475840) Cadmium levels ( 26025379) Hematocrit ( 29403010 28017375) Hemoglobin ( 29403010) Hemoglobin levels ( 28017375) Mean corpuscular hemoglobin ( 29403010 28453575 28017375) Mean corpuscular volume ( 29403010 28453575 20139978 28017375 19862010) Platelet count ( 29403010) Red blood cell count ( 29403010 28453575 28017375) Red blood cell traits ( 23222517) Schizophrenia ( 26198764) Serum VEGFR2 concentration ( 25411163) Systemic lupus erythematosus ( 29494758)
Interacting Genes		39 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL	60 interacting genes: ABL1 BTK CBL CBLB CD81 CD9 CISH CLTC CRK CRKL CSF1R CSF2RA CSF2RB DOK1 EPOR FYN GRAP GRAP2 GRB10 GRB2 GRB7 HCK IL7R ILKAP INPP5D JAK2 JAK3 KITLG LCK LYN MATK MPDZ PIK3CG PIK3R1 PIK3R2 PLCE1 PLCG1 PRKCA PRKCB PTPN11 PTPN20 PTPN6 PTPRO PTPRU RASA1 SH2B2 SH2B3 SOCS1 SOCS5 SOCS6 SPRED1 SPRED2 SRC STAP1 STAT1 STAT5A STAT5B STYX TEC YES1
Entrez ID		2057	3815
HPRD ID		00587	01287
Ensembl ID		ENSG00000187266	ENSG00000157404
Uniprot IDs		P19235	A0A0U2N547 P10721
PDB IDs		1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL	1PKG 1QZJ 1QZK 1R01 1T45 1T46 2E9W 2EC8 2IUH 2VIF 3G0E 3G0F 4HVS 4K94 4K9E 4PGZ 4U0I 6GQJ 6GQK 6GQL 6GQM 6HH1 6ITT 6ITV 6KLA 6MOB
Enriched GO Terms of Interacting Partners?
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