EPHA4 and ARHGEF15

Number of citations of the paper that reports this interaction (PubMedID 12775584)
35

Data Source:
HPRD (in vivo)

		EPHA4	ARHGEF15
Description		EPH receptor A4	Rho guanine nucleotide exchange factor 15
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Cell Surface Filopodium Axon Dendrite Neuromuscular Junction Early Endosome Membrane Neuron Projection Dendritic Spine Dendritic Shaft Perikaryon Receptor Complex Axon Terminus Axonal Growth Cone Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Cytoplasm Dendrite
	Molecular Function	Amyloid-beta Binding Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding ATP Binding Kinase Activity PH Domain Binding Identical Protein Binding Ephrin Receptor Binding DH Domain Binding Protein Tyrosine Kinase Binding	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Adult Walking Behavior Motor Neuron Axon Guidance Glial Cell Migration Negative Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Corticospinal Tract Morphogenesis Positive Regulation Of Kinase Activity Adherens Junction Organization Regulation Of GTPase Activity Positive Regulation Of JUN Kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway Negative Regulation Of Axon Regeneration Regulation Of Astrocyte Differentiation Regulation Of Axonogenesis Positive Regulation Of Dendrite Morphogenesis Protein Stabilization Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Nephric Duct Morphogenesis Cochlea Development Fasciculation Of Sensory Neuron Axon Fasciculation Of Motor Neuron Axon Neuron Projection Guidance Synapse Pruning Neuron Projection Fasciculation Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Amyloid-beta Regulation Of Modification Of Synaptic Structure Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity	Positive Regulation Of GTPase Activity Regulation Of Catalytic Activity Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Negative Regulation Of Synapse Maturation
Pathways		EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 26394188) Blond vs. brown/black hair color ( 30531825) Brain imaging ( 20100581) Brown vs. black hair color ( 30531825) Diffusing capacity of carbon monoxide ( 30694715) Diisocyanate-induced asthma ( 25918132) Entorhinal cortical volume ( 31530798) Face memory ( 31596458) Hair color ( 29662168) Heel bone mineral density ( 30598549) Immune response to measles-mumps-rubella vaccine ( 24811271) Nose size ( 27182965) Paclitaxel-induced neuropathy ( 23776197) Rostral anterior cingulate cortex volume ( 31530798) Urate levels in lean individuals ( 25811787)	Bipolar disorder ( 28115744) LDL cholesterol ( 30275531) Total cholesterol levels ( 30275531)
Interacting Genes		17 interacting genes: ARHGEF15 EFNA1 EFNA3 EFNA4 EFNA5 EFNB2 EFNB3 ERBB2 FGFR1 FGFR2 FGFR3 FGFR4 FYN IKBKG NGEF SRC TNS3	9 interacting genes: C11orf49 CEP55 DNAJC5 EPHA4 ESR1 ESRRG LASP1 MOB4 PIN1
Entrez ID		2043	22899
HPRD ID		03719	10535
Ensembl ID		ENSG00000116106	ENSG00000198844
Uniprot IDs		A1MA61 P54764	A0A0S2Z547 O94989
PDB IDs		2LW8 2WO1 2WO2 2WO3 3CKH 3GXU 4BK4 4BK5 4BKA 4BKF 4M4P 4M4R 4W4Z 4W50 5JR2
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?