EPB41L2 and GRIA1

Number of citations of the paper that reports this interaction (PubMedID 11050113)
109

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		EPB41L2	GRIA1
Description		erythrocyte membrane protein band 4.1 like 2	glutamate ionotropic receptor AMPA type subunit 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Spectrin COP9 Signalosome Cell Junction Extracellular Exosome Cell Cortex Region	Golgi Membrane Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface ER To Golgi Transport Vesicle Membrane Postsynaptic Density Cell Junction Dendrite Endocytic Vesicle Membrane Early Endosome Membrane AMPA Glutamate Receptor Complex Dendritic Spine Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Neuronal Cell Body Dendritic Spine Axonal Spine Neuron Spine Postsynaptic Membrane Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Synaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Actin Binding Structural Molecule Activity Protein Binding Spectrin Binding PH Domain Binding	Amyloid-beta Binding AMPA Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Cell Cycle Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Cell Division Positive Regulation Of Protein Localization To Cell Cortex	ER To Golgi Vesicle-mediated Transport Signal Transduction Chemical Synaptic Transmission Long-term Memory Receptor Internalization Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic COPII Vesicle Coating Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Long-term Synaptic Depression Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of NMDA Receptor Activity
Pathways		Neurexins and neuroligins	COPII-mediated vesicle transport Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Cargo concentration in the ER Synaptic adhesion-like molecules Long-term potentiation
Drugs			Glutamic Acid Enflurane Isoflurane Ethanol Methoxyflurane Desflurane Sevoflurane Talampanel CX717 Perampanel Fluciclovine (18F)
Diseases
GWAS		Cerebellum white matter volume ( 31530798) Colorectal cancer (calcium intake interaction) ( 25192705) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Lentiform nucleus volume ( 22903471) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Mean corpuscular volume ( 27863252) Pars triangularis volume ( 31530798) Response to statins (LDL cholesterol change) ( 22331829) Systolic blood pressure ( 30224653) Urolithiasis ( 30975718)	Aging (time to event) ( 21782286) Anthropometric traits ( 19260139) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Interleukin-6 levels ( 22205395) Middle childhood and early adolescence aggressive behavior ( 26087016) Morning person ( 30696823) Obesity-related traits ( 23251661) Post bronchodilator FEV1 in COPD ( 26634245) Schizophrenia ( 28991256 25056061 30285260 23974872) Sudden cardiac arrest ( 21658281) Survival in microsatellite instability low/stable colorectal cancer ( 25866641)
Interacting Genes		15 interacting genes: ACTA1 ADORA1 APP ATXN1L DRD1 DRD3 FKBP2 GRIA1 GRM1 HSPB1 NUMA1 SPTAN1 YWHAG YWHAH YWHAZ	24 interacting genes: CACNG2 CAMK2G CANX CASP8 CXCR2 DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 NEDD4L PICK1 PRKACA PRKCA SDCBP SQSTM1 TANC1 TRPC1 USP46
Entrez ID		2037	2890
HPRD ID		09126	00695
Ensembl ID		ENSG00000079819	ENSG00000155511
Uniprot IDs		B4DJ76 I6L9B1 O43491 Q59FD8	P42261 Q59GL5
PDB IDs
Enriched GO Terms of Interacting Partners?
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