GRIA1 and GRIA4

Number of citations of the paper that reports this interaction (PubMedID 9466455)
16

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GRIA1	GRIA4
Description		glutamate ionotropic receptor AMPA type subunit 1	glutamate ionotropic receptor AMPA type subunit 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface ER To Golgi Transport Vesicle Membrane Postsynaptic Density Cell Junction Dendrite Endocytic Vesicle Membrane Early Endosome Membrane AMPA Glutamate Receptor Complex Dendritic Spine Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Neuronal Cell Body Dendritic Spine Axonal Spine Neuron Spine Postsynaptic Membrane Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Synaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Plasma Membrane Cell Junction Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Postsynaptic Density Membrane Extracellular Vesicle
	Molecular Function	Amyloid-beta Binding AMPA Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Amyloid-beta Binding Ionotropic Glutamate Receptor Activity AMPA Glutamate Receptor Activity Glutamate Receptor Activity Ligand-gated Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	ER To Golgi Vesicle-mediated Transport Signal Transduction Chemical Synaptic Transmission Long-term Memory Receptor Internalization Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic COPII Vesicle Coating Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Long-term Synaptic Depression Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of NMDA Receptor Activity	Glutamate Receptor Signaling Pathway Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Regulation Of NMDA Receptor Activity
Pathways		COPII-mediated vesicle transport Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Cargo concentration in the ER Synaptic adhesion-like molecules Long-term potentiation	Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules
Drugs		Glutamic Acid Enflurane Isoflurane Ethanol Methoxyflurane Desflurane Sevoflurane Talampanel CX717 Perampanel Fluciclovine (18F)	Glutamic Acid Ethanol Talampanel CX717 Fluciclovine (18F)
Diseases
GWAS		Aging (time to event) ( 21782286) Anthropometric traits ( 19260139) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Interleukin-6 levels ( 22205395) Middle childhood and early adolescence aggressive behavior ( 26087016) Morning person ( 30696823) Obesity-related traits ( 23251661) Post bronchodilator FEV1 in COPD ( 26634245) Schizophrenia ( 28991256 25056061 30285260 23974872) Sudden cardiac arrest ( 21658281) Survival in microsatellite instability low/stable colorectal cancer ( 25866641)	Age at first sexual intercourse ( 27089180) Myopia ( 27182965) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Post bronchodilator FEV1 ( 26634245) Refractive error ( 23396134) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		24 interacting genes: CACNG2 CAMK2G CANX CASP8 CXCR2 DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 NEDD4L PICK1 PRKACA PRKCA SDCBP SQSTM1 TANC1 TRPC1 USP46	12 interacting genes: ACTN1 CACNG2 CAMK2G EPB41L1 GRIA1 GRIP1 IQGAP1 PICK1 PRKACA PRKCA PRKCG SDCBP
Entrez ID		2890	2893
HPRD ID		00695	00694
Ensembl ID		ENSG00000155511	ENSG00000152578
Uniprot IDs		P42261 Q59GL5	P48058 Q1WWK6
PDB IDs
Enriched GO Terms of Interacting Partners?
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