GRIA1 and CACNG2

Number of citations of the paper that reports this interaction (PubMedID 11140673)
372

Data Source:
HPRD (in vivo)

		GRIA1	CACNG2
Description		glutamate ionotropic receptor AMPA type subunit 1	calcium voltage-gated channel auxiliary subunit gamma 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Plasma Membrane Synaptic Vesicle Cell Surface ER To Golgi Transport Vesicle Membrane Postsynaptic Density Cell Junction Dendrite Endocytic Vesicle Membrane Early Endosome Membrane AMPA Glutamate Receptor Complex Dendritic Spine Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Neuronal Cell Body Dendritic Spine Axonal Spine Neuron Spine Postsynaptic Membrane Recycling Endosome Recycling Endosome Membrane Excitatory Synapse Synaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cell Surface Cell Junction Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Somatodendritic Compartment Cerebellar Mossy Fiber Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Amyloid-beta Binding AMPA Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Ligand-gated Ion Channel Activity PDZ Domain Binding Signaling Receptor Activity Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Voltage-gated Calcium Channel Activity Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	ER To Golgi Vesicle-mediated Transport Signal Transduction Chemical Synaptic Transmission Long-term Memory Receptor Internalization Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic COPII Vesicle Coating Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Long-term Synaptic Depression Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of NMDA Receptor Activity	Protein Targeting To Membrane Neuromuscular Junction Development Transmission Of Nerve Impulse Response To Calcium Ion Membrane Depolarization Membrane Hyperpolarization Eye Blink Reflex Cardiac Conduction Calcium Ion Transmembrane Transport Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Postsynaptic Neurotransmitter Receptor Diffusion Trapping Neurotransmitter Receptor Internalization Positive Regulation Of Protein Localization To Basolateral Plasma Membrane Regulation Of AMPA Receptor Activity Positive Regulation Of AMPA Receptor Activity
Pathways		COPII-mediated vesicle transport Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Cargo concentration in the ER Synaptic adhesion-like molecules Long-term potentiation	Presynaptic depolarization and calcium channel opening Trafficking of AMPA receptors Phase 0 - rapid depolarisation Phase 2 - plateau phase LGI-ADAM interactions
Drugs		Glutamic Acid Enflurane Isoflurane Ethanol Methoxyflurane Desflurane Sevoflurane Talampanel CX717 Perampanel Fluciclovine (18F)	Ethanol
Diseases
GWAS		Aging (time to event) ( 21782286) Anthropometric traits ( 19260139) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 20592726) Chronotype ( 30696823) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Interleukin-6 levels ( 22205395) Middle childhood and early adolescence aggressive behavior ( 26087016) Morning person ( 30696823) Obesity-related traits ( 23251661) Post bronchodilator FEV1 in COPD ( 26634245) Schizophrenia ( 28991256 25056061 30285260 23974872) Sudden cardiac arrest ( 21658281) Survival in microsatellite instability low/stable colorectal cancer ( 25866641)	Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)
Interacting Genes		24 interacting genes: CACNG2 CAMK2G CANX CASP8 CXCR2 DLG1 EPB41L1 EPB41L2 GRIA4 GRID2 GRIK2 GRIP1 GRIPAP1 HOMER1 HSPA5 NEDD4L PICK1 PRKACA PRKCA SDCBP SQSTM1 TANC1 TRPC1 USP46	10 interacting genes: APP DLG1 DLG2 DLG3 DLG4 GRIA1 GRIA4 PATJ PRKACA SRPK2
Entrez ID		2890	10369
HPRD ID		00695	04220
Ensembl ID		ENSG00000155511	ENSG00000166862
Uniprot IDs		P42261 Q59GL5	Q9Y698
PDB IDs			6DLZ 6DM0 6DM1 6O9G
Enriched GO Terms of Interacting Partners?
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