EP300 and MEF2C

Number of citations of the paper that reports this interaction (PubMedID 9001254)
119

Data Source:
HPRD (in vitro)

		EP300	MEF2C
Description		E1A binding protein p300	myocyte enhancer factor 2C
Image			No pdb structure
GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Transcription Factor Complex Chromosome Cytosol Protein-DNA Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Sarcoplasm Nuclear Speck Protein-containing Complex Intracellular Membrane-bounded Organelle Postsynapse
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding P53 Binding DNA Binding Chromatin Binding Damaged DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity Transferase Activity, Transferring Acyl Groups Chromatin DNA Binding Activating Transcription Factor Binding Nuclear Hormone Receptor Binding Tau Protein Binding Androgen Receptor Binding NF-kappaB Binding Peptide-lysine-N-acetyltransferase Activity Protein Propionyltransferase Activity Pre-mRNA Intronic Binding STAT Family Protein Binding Peptide Butyryltransferase Activity Histone Crotonyltransferase Activity Histone Butyryltransferase Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific AT DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Activating Transcription Factor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Somitogenesis Thigmotaxis Behavioral Defense Response Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Glycolytic Process Transcription-coupled Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Protein Acetylation Internal Protein Amino Acid Acetylation Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Nervous System Development Heart Development Skeletal Muscle Tissue Development Learning Or Memory Circadian Rhythm Animal Organ Morphogenesis Regulation Of Autophagy Macrophage Derived Foam Cell Differentiation Regulation Of Mitochondrion Organization Positive Regulation Of Neuron Projection Development Viral Process Histone Acetylation Protein Deubiquitination N-terminal Peptidyl-lysine Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation B Cell Differentiation Platelet Formation Lung Development Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Complex Assembly Protein Destabilization Positive Regulation Of Protein Binding Positive Regulation Of Type I Interferon Production Cellular Response To UV Multicellular Organism Growth Megakaryocyte Development Swimming Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Response To Estrogen Positive Regulation By Host Of Viral Transcription Histone H4 Acetylation Histone H2B Acetylation Fat Cell Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gluconeogenesis Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Face Morphogenesis Regulation Of Androgen Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Peptidyl-lysine Propionylation Regulation Of Tubulin Deacetylation Peptidyl-lysine Crotonylation Peptidyl-lysine Butyrylation Regulation Of Cellular Response To Heat Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Signal Transduction By P53 Class Mediator Beta-catenin-TCF Complex Assembly Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Blood Vessel Development Osteoblast Differentiation Neuron Migration B Cell Homeostasis Heart Looping Endochondral Ossification Blood Vessel Remodeling Chondrocyte Differentiation Germinal Center Formation Regulation Of Germinal Center Formation Primary Heart Field Specification Secondary Heart Field Specification Outflow Tract Morphogenesis Sinoatrial Valve Morphogenesis Cardiac Ventricle Formation Regulation Of Transcription, DNA-templated Apoptotic Process Humoral Immune Response Multicellular Organism Development Nervous System Development Heart Development Muscle Organ Development Skeletal Muscle Tissue Development Muscle Cell Fate Determination Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Alkaline Phosphatase Activity Neural Crest Cell Differentiation Cardiac Muscle Hypertrophy In Response To Stress Myotube Differentiation Neuron Differentiation Platelet Formation Monocyte Differentiation Negative Regulation Of Ossification Melanocyte Differentiation Positive Regulation Of Bone Mineralization Positive Regulation Of B Cell Proliferation Cellular Response To Drug Skeletal Muscle Cell Differentiation Cellular Response To Trichostatin A B Cell Proliferation Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Megakaryocyte Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Plasticity Positive Regulation Of Skeletal Muscle Tissue Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Embryonic Viscerocranium Morphogenesis B Cell Receptor Signaling Pathway Smooth Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Ventricular Cardiac Muscle Cell Differentiation Roof Of Mouth Development Regulation Of Synaptic Activity Positive Regulation Of Cardiac Muscle Cell Proliferation Excitatory Postsynaptic Potential Regulation Of Sarcomere Organization Cartilage Morphogenesis Regulation Of Dendritic Spine Development Renal Tubule Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cell Proliferation In Bone Marrow Glomerulus Morphogenesis Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Protein Homodimerization Activity Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Macrophage Apoptotic Process Regulation Of NMDA Receptor Activity Regulation Of AMPA Receptor Activity Positive Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Behavioral Fear Response Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression RORA activates gene expression Polo-like kinase mediated events Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock Circadian Clock B-WICH complex positively regulates rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis CD209 (DC-SIGN) signaling Metalloprotease DUBs Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NGF-stimulated transcription NGF-stimulated transcription TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation FOXO-mediated transcription of cell death genes Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation	ERK/MAPK targets Transcriptional activation of mitochondrial biogenesis Circadian Clock Myogenesis MECP2 regulates transcription factors
Drugs
Diseases		Rubinstein-Taybi syndrome	Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 22936669) General risk tolerance (MTAG) ( 30643258) Neuroticism ( 29255261) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30297969)	Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 29325848) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Body mass index ( 26426971) Bone mineral density ( 21533022 24249740 23572186) Bone mineral density (hip) ( 19801982) Bone mineral density (total hip) ( 29883787) Bone mineral density (Ward's triangle area) ( 27397699) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Depression ( 29700475) Femoral neck bone mineral density ( 29499414 22504420) General cognitive ability ( 29844566) Glomerular filtration rate in chronic kidney disease ( 26420894) Height ( 20881960 25282103 25429064) Household income (MTAG) ( 31844048) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 27479909) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Mean platelet volume ( 22139419 27863252) Morning person ( 30696823) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Red blood cell count ( 27863252) Regular attendance at a religious group ( 29970889) Retinal arteriolar caliber ( 23776548) Retinal vascular caliber ( 21060863) Rosacea symptom severity ( 29771307) Schizophrenia ( 25056061 30285260) Smoking status (ever vs never smokers) ( 30643258) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Tonometry ( 17903302) Vascular endothelial growth factor levels ( 26910538) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		372 interacting genes: ABL1 ACSM5 ACTA2 ACTB AHR AKT1 ALKBH4 ALX1 APEX1 AR ARHGDIA ARNT ARNTL ARSF ASCL1 ASH2L ATF4 ATF5 ATR AUTS2 BAG6 BCAS2 BCL3 BCL6 BRCA1 BRMS1 C1R CALCOCO1 CARM1 CCNB1 CCND1 CDK1 CDK2 CDT1 CDX2 CEBPA CEBPB CEBPD CFH CHD4 CITED1 CITED2 CITED4 CLOCK CNOT4 COPS2 COPS6 CREBBP CRX CTBP1 CTBP2 CTF1 CTNNB1 CXCL8 CXXC1 DAO DBP DDIT3 DDX24 DDX5 DECR2 DEK DTX1 DUX4 E2F1 E2F5 EEF1A1 EEF2 EGR1 EID1 EID2 ELF3 ELK1 EMB EPAS1 EPO ESR1 ESR2 ETS1 ETS2 ETV1 ETV4 FBXL5 FEN1 FHL2 FOSB FOSL1 FOSL2 FOXO3 FOXP3 GAA GABPA GATA2 GATA4 GATA5 GATA6 GCKR GLUL GOLGA2 GPBP1 GPS2 GRB2 GRIP1 GTF2B H1-1 H1-3 H2AC20 H2AC21 H2AC4 H2BC21 H2BC3 H3-3A H3-4 H3C1 H3C14 H4-16 H4C14 H4C9 HAND2 HBP1 HDAC1 HDAC3 HDAC6 HEMGN HERC1 HIF1A HIPK2 HMGB1 HMGN1 HMGN2 HNF1A HNRNPU HNRNPUL1 HOXA10 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD4 HPS6 HSP90AA2P ILF2 ILF3 IMMT ING1 ING2 ING4 ING5 IRF1 IRF2 IRF3 IRF5 IRF7 ITIH3 JDP2 JMY JUN JUNB JUND KAT2A KAT2B KAT5 KCTD5 KLF1 KLF13 KLF2 KLF4 KLF5 KPNA2 KRT18 LEF1 MAF MAGED1 MAML1 MAP2K1 MAP3K5 MAPK1 MAPK8 MAPT MAX MCL1 MCM2 MCM3 MCM3AP MCM4 MCM5 MDC1 MDM2 MDM4 MEF2A MEF2C MEF2D MGMT MITF MN1 MORF4L1 MPG MRE11 MSH6 MSTO1 MTOR MYB MYBL2 MYC MYOD1 N4BP2 NAP1L1 NAP1L4 NBN NCOA1 NCOA2 NCOA3 NCOA6 NEDD1 NEIL2 NEUROD1 NFATC1 NFATC2 NFYB NOTCH1 NOXA1 NPAS2 NPM1 NR1H4 NR1I2 NR2F2 NR4A1 NUP98 NUPR1 OLIG2 ORC2 PAK2 PAX5 PAX6 PAX8 PAXIP1 PCK2 PCNA PDHX PELP1 PIAS1 PIAS3 PIN1 PLAGL1 PLG PLSCR1 PLSCR2 PML POLB POLD2 POLI POU3F2 PPARA PPARD PPP2R5C PRKCA PRKCB PRKCD PRKDC PRMT1 PROX1 PTMA RACK1 RAD23A RAD50 RAN RB1 RBM14 RBX1 RECQL4 REL RELA RORA RPL27 RPS6KA5 RPS6KB1 RPS6KB2 RUNX1 RUNX2 RUNX3 RUVBL2 SATB1 SAV1 SELENOP SENP3 SERTAD1 SET SETD1A SIRT1 SIRT2 SKP2 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD7 SNAI1 SNIP1 SNW1 SOX9 SP1 SP3 SPHK1 SPIB SREBF1 SREBF2 SRY SS18 SS18L1 STAT1 STAT2 STAT3 STAT5A STAT5B STAT6 SUB1 SUMO2 SUV39H1 TACC2 TADA3 TAF1B TAL1 TCF12 TCF3 TCF4 TCF7L2 TDG TERF2 TFAP2A TGFB1I1 TGS1 THPO TINAGL1 TNIP2 TP53 TP53BP1 TP63 TP73 TRAF2 TRERF1 TRIP4 TSG101 TWIST1 UBC UBE2D1 UBE2I UBQLN1 UBTF USF2 VPS18 WDR59 WDR82 XRCC6 YWHAZ YY1 ZBTB16 ZBTB17 ZBTB48 ZBTB49 ZBTB7B ZBTB8A ZC3H12A ZEB1 ZFPM2 ZNF148 ZNF76 ZRANB2	30 interacting genes: ASCL1 CCNB1 CDK1 COPS5 CSNK2A1 EP300 EPAS1 GATA4 HDAC4 HDAC5 HDAC7 HDAC9 MAPK14 MAPK7 MEF2D MYOD1 MYOG NCOA2 NOTCH1 PLA2G12A SMAD2 SOX18 SP1 SPTBN1 TEAD1 TWIST2 UBE2I VGLL2 VGLL4 YWHAZ
Entrez ID		2033	4208
HPRD ID		04078	02809
Ensembl ID		ENSG00000100393	ENSG00000081189
Uniprot IDs		Q09472 Q7Z6C1	A0A024RAL6 A0A024RAL7 A0A0D9SGI5 D8L7E9 Q06413
PDB IDs		1L3E 1P4Q 2K8F 2MH0 2MZD 3BIY 3I3J 3IO2 3P57 3T92 4BHW 4PZR 4PZS 4PZT 5BT3 5KJ2 5LKT 5LKU 5LKX 5LKZ 5LPK 5LPM 5NU5 5XZC 6DS6 6FGN 6FGS 6GYR 6GYT 6K4N 6PF1 6PGU
Enriched GO Terms of Interacting Partners?
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